Distribution of Nidogen in the Murine Eye and Ocular Phenotype of the Nidogen-1 Knockout Mouse
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Distribution and lack of nidogen-1, part of numerous basement membranes, were studied in the mouse eye.
For that purpose, eyes of C57BL/6 and nidogen-1 knockout mice were stained immunohistochemically for nidogen-1, and intraocular pressure measurements and light- and electron microscopy were used to study the nidogen-1 knockout animals.
In normal mice, nidogen-1 was present in many basement membranes, but showed irregularities underneath the corneal epithelium, in Bruch’s membrane and in the iris.
Homozygous knockout of nidogen-1 in the mouse showed only mild pathological changes.
In the anterior eye segment, small interruptions were noted in the nonpigmented ciliary epithelium without further consequences.
In the posterior eye segment, interruptions of the inner limiting membrane led to small retinal ectopias and subsequent changes in the optic nerve.
In summary, the knockout of nidogen-1 showed mild but significant morphological changes pointing to the importance of this protein which can in part, but not completely; be replaced by nidogen-2.
American Psychological Association (APA)
May, Christian Albrecht. 2012. Distribution of Nidogen in the Murine Eye and Ocular Phenotype of the Nidogen-1 Knockout Mouse. ISRN Ophthalmology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-467342
Modern Language Association (MLA)
May, Christian Albrecht. Distribution of Nidogen in the Murine Eye and Ocular Phenotype of the Nidogen-1 Knockout Mouse. ISRN Ophthalmology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-467342
American Medical Association (AMA)
May, Christian Albrecht. Distribution of Nidogen in the Murine Eye and Ocular Phenotype of the Nidogen-1 Knockout Mouse. ISRN Ophthalmology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-467342
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467342