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Neuron Regeneration and Proliferation Effects of Danshen and Tanshinone IIA
Joint Authors
Chou, Ming-Chih
Wang, Hwai-Lee
Peng, Wen-Huang
Huang, Chih-Yang
Shen, Jui-Lung
Lin, Jing-Ying
Tsai, Fuu-Jen
Lin, Chien-Chung
Chen, Yueh-Sheng
Tzang, Bor-Show
Tien, Yun-Chen
Kuo, Chia-Hua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study evaluates the proliferative effects of danshen and its monomer extract, tanshinone IIA, on Schwann cell proliferation.
A piece of silicone rubber was guided across a 15-mm gap in the sciatic nerve of a rat.
This nerve gap was then filled with different concentrations of danshen (0–100 mg/mL).
The results showed that danshen increased the expressions of uPA, cyclin D1, E and ERK, JNK, and P38 MAP kinases via the FGF-2 signaling pathway in a dose-dependent manner.
RSC96, Schwann cells were also administered with danshen (0, 20, 40, 60, 80, and 100 μg/mL) and tanshinone IIA (0, 2, 4, 6, 8, and 10 μg/mL).
In lower concentrations, danshen and tanshinone IIA exhibited an apparent effect on Schwann cells.
Similar effects were also demonstrated in the FGF-2-uPA regulating cascade and cell cycle proliferative protein results.
Schwann cell migration was elevated as well.
We used MAPK-signaling chemical inhibitors and identified the proliferative effects of danshen and tanshinone IIA as MAPK-signaling dependent.
The results from the in vitro systems indicate that danshen and tanshinone IIA can be used to induce Schwann cell proliferation, and in vivo results potentially suggest that danshen and tanshinone IIA might enhance neuron regeneration.
American Psychological Association (APA)
Shen, Jui-Lung& Chen, Yueh-Sheng& Lin, Jing-Ying& Tien, Yun-Chen& Peng, Wen-Huang& Kuo, Chia-Hua…[et al.]. 2010. Neuron Regeneration and Proliferation Effects of Danshen and Tanshinone IIA. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-467357
Modern Language Association (MLA)
Shen, Jui-Lung…[et al.]. Neuron Regeneration and Proliferation Effects of Danshen and Tanshinone IIA. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-467357
American Medical Association (AMA)
Shen, Jui-Lung& Chen, Yueh-Sheng& Lin, Jing-Ying& Tien, Yun-Chen& Peng, Wen-Huang& Kuo, Chia-Hua…[et al.]. Neuron Regeneration and Proliferation Effects of Danshen and Tanshinone IIA. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-467357
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467357