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FGF-23 Levels before and after Renal Transplantation
Joint Authors
Memmos, Dimitrios
Dovas, Spyros
Papagianni, Aikaterini
Economidou, Domniki
Pateinakis, Panagiotis
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-05-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Phosphatonin fibroblast growth factor-23 (FGF-23) is involved in phosphate (P) excretion and vitamin D metabolism.
Recently, FGF-23 has been suggested to be responsible for the hypophosphatemia and inappropriately low calcitriol levels observed after renal transplantation.
We performed a prospective study to investigate FGF-23 levels in patients with end-stage renal disease before and after renal transplantation and their probable association with markers of bone and mineral metabolism.
Intact FGF-23 levels were determined before and at 3, 6, and 12 months posttransplantation in 18 renal transplant recipients.
Intact parathyroid hormone (iPTH), calcium (Ca), P, 25(OH)VitD, and 1,25(OH)2VitD levels were measured at the same time periods.
Renal threshold phosphate concentration (TmPO4/GFR) was also calculated at 3, 6, and 12 months posttransplantation.
The results showed that FGF-23 levels decreased by 89% 3 months posttransplantation (346 ± 146 versus 37 ± 9 pg/mL, P<.01) and remained stable throughout the study period.
iPTH and P levels also decreased significantly after renal transplantation, while Ca and 1,25(OH)2VitD increased.
Pretransplantation FGF-23 was significantly correlated with P levels at 3 months posttransplantation (P<.005).
In conclusion, FGF-23 levels decrease dramatically after successful renal transplantation.
Pre-transplantation FGF-23 correlate with P levels 3 months posttransplantation.
American Psychological Association (APA)
Economidou, Domniki& Dovas, Spyros& Papagianni, Aikaterini& Pateinakis, Panagiotis& Memmos, Dimitrios. 2009. FGF-23 Levels before and after Renal Transplantation. Journal of Transplantation،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-467374
Modern Language Association (MLA)
Economidou, Domniki…[et al.]. FGF-23 Levels before and after Renal Transplantation. Journal of Transplantation No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-467374
American Medical Association (AMA)
Economidou, Domniki& Dovas, Spyros& Papagianni, Aikaterini& Pateinakis, Panagiotis& Memmos, Dimitrios. FGF-23 Levels before and after Renal Transplantation. Journal of Transplantation. 2009. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-467374
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467374