Neuromuscular Junction Protection for the Potential Treatment of Amyotrophic Lateral Sclerosis
Joint Authors
Krakora, Dan
Suzuki, Masatoshi
Macrander, Corey
Source
Neurology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease characterized by the progressive degeneration of upper and lower motor neurons (MNs), leading to muscular atrophy and eventual respiratory failure.
ALS research has primarily focused on mechanisms regarding MN cell death; however, degenerative processes in the skeletal muscle, particularly involving neuromuscular junctions (NMJs), are observed in the early stages of and throughout disease progression.
According to the “dying-back” hypothesis, NMJ degeneration may not only precede, but actively cause upper and lower MN loss.
The importance of NMJ pathology has relatively received little attention in ALS, possibly because compensatory mechanisms mask NMJ loss for prolonged periods.
Many mechanisms explaining NMJ degeneration have been proposed such as the disruption of anterograde/retrograde axonal transport, irregular cellular metabolism, and changes in muscle gene and protein expression.
Neurotrophic factors, which are known to have neuroprotective and regenerative properties, have been intensely investigated for their therapeutic potential in both the preclinical and clinical setting.
Additional research should focus on the potential of preserving NMJs in order to delay or prevent disease progression
American Psychological Association (APA)
Krakora, Dan& Macrander, Corey& Suzuki, Masatoshi. 2012. Neuromuscular Junction Protection for the Potential Treatment of Amyotrophic Lateral Sclerosis. Neurology Research International،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-467430
Modern Language Association (MLA)
Krakora, Dan…[et al.]. Neuromuscular Junction Protection for the Potential Treatment of Amyotrophic Lateral Sclerosis. Neurology Research International No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-467430
American Medical Association (AMA)
Krakora, Dan& Macrander, Corey& Suzuki, Masatoshi. Neuromuscular Junction Protection for the Potential Treatment of Amyotrophic Lateral Sclerosis. Neurology Research International. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-467430
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467430