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Nongenomic Mechanisms of PTEN Regulation
Joint Authors
Fata, Jimmie E.
Debnath, Shawon
Jenkins, Edmund C.
Fournier, Marcia V.
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A large amount of data supports the view that PTEN is a bona fide tumor suppressor gene.
However, recent evidence suggests that derailment of cellular localization and expression levels of functional nonmutated PTEN is a determining force in inducing abnormal cellular and tissue outcomes.
As the cellular mechanisms that regulate normal PTEN enzymatic activity resolve, it is evident that deregulation of these mechanisms can alter cellular processes and tissue architecture and ultimately lead to oncogenic transformation.
Here we discuss PTEN ubiquitination, PTEN complex formation with components of the adherens junction, PTEN nuclear localization, and microRNA regulation of PTEN as essential regulatory mechanisms that determine PTEN function independent of gene mutations and epigenetic events.
American Psychological Association (APA)
Fata, Jimmie E.& Debnath, Shawon& Jenkins, Edmund C.& Fournier, Marcia V.. 2012. Nongenomic Mechanisms of PTEN Regulation. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-467432
Modern Language Association (MLA)
Fata, Jimmie E.…[et al.]. Nongenomic Mechanisms of PTEN Regulation. International Journal of Cell Biology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-467432
American Medical Association (AMA)
Fata, Jimmie E.& Debnath, Shawon& Jenkins, Edmund C.& Fournier, Marcia V.. Nongenomic Mechanisms of PTEN Regulation. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-467432
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467432