64Cu-NODAGA-c(RGDyK) Is a Promising New Angiogenesis PET Tracer : Correlation between Tumor Uptake and Integrin αVβ3 Expression in Human Neuroendocrine Tumor Xenografts
Joint Authors
Madsen, Jacob
Kjaer, Andreas
Schjoeth-Eskesen, Christina
Oxboel, Jytte
El-Ali, Henrik H.
Source
International Journal of Molecular Imaging
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Purpose.
The purpose of this paper is to evaluate a new PET tracer 64Cu-NODAGA-c(RGDyK) for imaging of tumor angiogenesis using gene expression of angiogenesis markers as reference and to estimate radiation dosimetry for humans.
Procedures.
Nude mice with human neuroendocrine tumor xenografts (H727) were administered 64Cu-NODAGA-c(RGDyK) i.v.
for study of biodistribution as well as for dynamic PET.
Gene expression of angiogenesis markers integrin αV, integrin β3, and VEGF-A were analyzed using QPCR and correlated to the tracer uptake in the tumors (%ID/g).
From biodistribution data human radiation-absorbed doses were estimated using OLINDA/EXM.
Results.
Tumor uptake was 1.2%ID/g with strong correlations between gene expression and tracer uptake, for integrin αV R=0.76, integrin β3 R=0.75 and VEGF-A R=0.81 (all P<0.05).
The whole body effective dose for humans was estimated to be 0.038 and 0.029 mSv/MBq for females and males, respectively, with highest absorbed dose in bladder wall.
Conclusion.
64Cu-NODAGA-c(RGDyK) is a promising new angiogenesis PET tracer with potential for human use.
American Psychological Association (APA)
Oxboel, Jytte& Schjoeth-Eskesen, Christina& El-Ali, Henrik H.& Madsen, Jacob& Kjaer, Andreas. 2012. 64Cu-NODAGA-c(RGDyK) Is a Promising New Angiogenesis PET Tracer : Correlation between Tumor Uptake and Integrin αVβ3 Expression in Human Neuroendocrine Tumor Xenografts. International Journal of Molecular Imaging،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-467446
Modern Language Association (MLA)
Oxboel, Jytte…[et al.]. 64Cu-NODAGA-c(RGDyK) Is a Promising New Angiogenesis PET Tracer : Correlation between Tumor Uptake and Integrin αVβ3 Expression in Human Neuroendocrine Tumor Xenografts. International Journal of Molecular Imaging No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-467446
American Medical Association (AMA)
Oxboel, Jytte& Schjoeth-Eskesen, Christina& El-Ali, Henrik H.& Madsen, Jacob& Kjaer, Andreas. 64Cu-NODAGA-c(RGDyK) Is a Promising New Angiogenesis PET Tracer : Correlation between Tumor Uptake and Integrin αVβ3 Expression in Human Neuroendocrine Tumor Xenografts. International Journal of Molecular Imaging. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-467446
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467446