Neurological Adverse Effects in Patients of Advanced Colorectal Carcinoma Treated with Different Schedules of FOLFOX
Joint Authors
Mateen, Ahmed
Bano, Nusrat
Najam, Rahila
Source
Chemotherapy Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The study is designed to assess the frequency and severity of few dose limiting neurological adverse effects of four different schedules of FOLFOX.
Patients with histologically confirmed advanced colorectal carcinoma (CRC) were included in the study.
Toxicity was graded according to CTC v 2.0.
The frequency of grade 3 and 4 adverse effects was comparatively assessed in each treatment arm.
The difference in the pattern of toxicity between the treatment schedule was evaluated.
The most frequent adverse symptom of neurological adverse effect was grade 1 paresthesia in the patients treated with FOLFOX4 schedule.
Grade 4 peripheral neuropathy was reported in few patients of FOLFOX7 treatment arm.
Frequency and onset of neurological adverse effects like paresthesia, dizziness, and hypoesthesia were significantly different (P<0.05), whereas frequency and onset of peripheral neuropathy were highly significant (P<0.01) in each treatment arm of FOLFOX.
Peripheral neuropathy was associated with electrolyte imbalance and diabetes in few patients.
Frequency of symptoms, for example, paresthesia, is associated with increased number of recurrent exposure to oxaliplatin (increased number of cycles) even at low doses (85 mg/m2), whereas severity of symptoms, for example, peripheral neuropathy, is associated with higher dose (130 mg/m2) after few treatment cycles.
American Psychological Association (APA)
Bano, Nusrat& Najam, Rahila& Mateen, Ahmed. 2013. Neurological Adverse Effects in Patients of Advanced Colorectal Carcinoma Treated with Different Schedules of FOLFOX. Chemotherapy Research and Practice،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-467454
Modern Language Association (MLA)
Bano, Nusrat…[et al.]. Neurological Adverse Effects in Patients of Advanced Colorectal Carcinoma Treated with Different Schedules of FOLFOX. Chemotherapy Research and Practice No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-467454
American Medical Association (AMA)
Bano, Nusrat& Najam, Rahila& Mateen, Ahmed. Neurological Adverse Effects in Patients of Advanced Colorectal Carcinoma Treated with Different Schedules of FOLFOX. Chemotherapy Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-467454
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467454