Significance of Glutathione Peroxidase 1 and Caudal-Related Homeodomain Transcription Factor in Human Gastric Adenocarcinoma
Joint Authors
Wu, Gong Fa
Wang, Li Li
Chen, Yan Xian
Huang, Zhi Quan
Li, Hai Gang
Xie, De-rong
Han, Jing Jing
Wei, Ying
Liu, Ye Qing
Sun, Qing
Source
Gastroenterology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
To investigate the expressions of glutathione peroxidase 1 (GPX1) and caudal-related homeodomain transcription factor (CDX2) in GAC and their correlation with clinicopathological features and tumor cell proliferation.
Methods.
The expressions of GPX1, CDX2, and Ki67 were immunohistochemically evaluated in 172 GAC specimens.
The association of GPX1 and CDX2 with patient’s clinicopathological features and Ki67 positive rate was analyzed statistically.
Results.
In 172 cases of GAC, the expression of GPX1 was weaker than that in adjacent normal mucosa, and the expression of CDX2 was higher than that in adjacent normal mucosa.
High expression GPX1 strong-expression was associated with differentiation, Lauren type, WHO type and extensive lymph node metastasis of GAC.
High expression of CDX2 was associated with differentiation, Lauren type, WHO type, extensive lymph node metastasis, and TNM of GAC.
Survival curves showed that expressions of GPX1 and CDX2 were factors of good outcome (P=.03 and .02, resp.).
According to multivariate analysis, only lymph node metastasis, TNM stage, and CDX2 expression were independently associated with survival.
In addition, a strong association of GPX1 expression was noted with Ki67 and CDX2.
Conclusions.
The expression of GPX1 and CDX2 may play a role in the carcinogenesis, differentiation, and progression of GAC, and CDX2 may be an independent prognostic factor.
American Psychological Association (APA)
Han, Jing Jing& Xie, De-rong& Wang, Li Li& Liu, Ye Qing& Wu, Gong Fa& Sun, Qing…[et al.]. 2013. Significance of Glutathione Peroxidase 1 and Caudal-Related Homeodomain Transcription Factor in Human Gastric Adenocarcinoma. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-467463
Modern Language Association (MLA)
Han, Jing Jing…[et al.]. Significance of Glutathione Peroxidase 1 and Caudal-Related Homeodomain Transcription Factor in Human Gastric Adenocarcinoma. Gastroenterology Research and Practice No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-467463
American Medical Association (AMA)
Han, Jing Jing& Xie, De-rong& Wang, Li Li& Liu, Ye Qing& Wu, Gong Fa& Sun, Qing…[et al.]. Significance of Glutathione Peroxidase 1 and Caudal-Related Homeodomain Transcription Factor in Human Gastric Adenocarcinoma. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-467463
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467463