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KCTD11 Tumor Suppressor Gene Expression Is Reduced in Prostate Adenocarcinoma
Joint Authors
Vecchiotti, Davide
Gulino, Alberto
Gallo, Rita
Capece, Daria
Tessitore, Alessandra
Verzella, Daniela
Fischietti, Mariafausta
Alesse, Edoardo
Nicosia, Daniela
Zazzeroni, Francesca
Ventura, Luca
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Prostate cancer is the most common noncutaneous cancer among men in the United States.
A genetic contribution to prostate cancer risk has been documented, but knowledge of the molecular mechanisms involved in prostate cancer initiation is still not well understood.
Loss of heterozygosity (LOH) of chromosomal regions is crucial in tumor progression.
In human prostate cancer, several chromosomal regions demonstrating a high frequency of LOH have been previously identified.
KCTD11 (REN) is a tumor suppressor gene mapping on human chromosome 17p13.2, whose expression is frequently lost in human medulloblastoma and in several other cancer types.
KCTD11 acts as a negative regulator of the Hedgehog (Hh) signaling.
Here, we demonstrated that KCTD11 LOH is a common genetic lesion in human prostate adenocarcinoma.
Indeed, nuclear KCTD11 protein expression is strongly reduced in primary prostate cancer, and this event correlated with overexpression of proteins acting into the Hedgehog pathway.
Low levels of KCTD11 mRNA have been also observed in prostatic cancer cells, and ectopic overexpression of KCTD11 led to growth arrest.
Our study demonstrates and supports that KCTD11, as well as negatively regulated downstream effectors belonging to Hh signaling, plays a role in prostate cancer pathogenesis.
This could be suitable to characterize new diagnostic and therapeutic markers.
American Psychological Association (APA)
Zazzeroni, Francesca& Nicosia, Daniela& Tessitore, Alessandra& Gallo, Rita& Verzella, Daniela& Fischietti, Mariafausta…[et al.]. 2014. KCTD11 Tumor Suppressor Gene Expression Is Reduced in Prostate Adenocarcinoma. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-467481
Modern Language Association (MLA)
Zazzeroni, Francesca…[et al.]. KCTD11 Tumor Suppressor Gene Expression Is Reduced in Prostate Adenocarcinoma. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-467481
American Medical Association (AMA)
Zazzeroni, Francesca& Nicosia, Daniela& Tessitore, Alessandra& Gallo, Rita& Verzella, Daniela& Fischietti, Mariafausta…[et al.]. KCTD11 Tumor Suppressor Gene Expression Is Reduced in Prostate Adenocarcinoma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-467481
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467481