HPV11 Positive Endometrioid Carcinoma of the Endometrium with Signet-Ring Cells : Diagnostic Criteria and Review of the Literature

Abstract EN

The presence of signet-ring cells in an endometrial adenocarcinoma is extremely uncommon and it is always necessary to rule out a metastatic neoplasm.

We report a FIGO grade 2 endometrial carcinoma with a signet-ring cell component found in the curettage performed to a 53-year-old woman.

The neoplastic proliferation was also found in the endometrium of the radical hysterectomy with bilateral salpingo-oophorectomy and pelvic and para-aortic lymphadenectomy.

The uterine neoplasm invaded less than one-half of the myometrium (FIGO stage I B).

Alcian blue showed the presence of mucin in the signet-ring cells.

The patient was alive and without evidence of recurrence 14 months after surgery.

Polymerase chain reaction method from paraffin-embedded tissue revealed the presence of human papilloma virus type 11.

We have discussed the differential diagnosis of this kind of neoplasm and we have reviewed the literature on signet-ring cell carcinoma of the endometrium.