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Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease
Joint Authors
Verma, Sheetal
Bunting, Kevin D.
Vaughan, Tamisha
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The Grb-2 associated binder (Gab) family of scaffolding/adaptor/docking proteins is a group of three molecules with significant roles in cytokine receptor signaling.
Gabs possess structural motifs for phosphorylation-dependent receptor recruitment, Grb2 binding, and activation of downstream signaling pathways through p85 and SHP-2.
In addition, Gabs participate in hematopoiesis and regulation of immune response which can be aberrantly activated in cancer and inflammation.
The multifunctionality of Gab adapters might suggest that they would be too difficult to consider as candidates for “targeted” therapy.
However, the one drug/one target approach is giving way to the concept of one drug/multiple target approach since few cancers are addicted to a single signaling molecule for survival and combination drug therapies can be problematic.
In this paper, we cover recent findings on Gab multi-functionality, binding partners, and their role in hematological malignancy and examine the concept of Gab-targeted therapy.
American Psychological Association (APA)
Verma, Sheetal& Vaughan, Tamisha& Bunting, Kevin D.. 2011. Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease. Advances in Hematology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-467502
Modern Language Association (MLA)
Verma, Sheetal…[et al.]. Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease. Advances in Hematology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-467502
American Medical Association (AMA)
Verma, Sheetal& Vaughan, Tamisha& Bunting, Kevin D.. Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease. Advances in Hematology. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-467502
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467502