Vaccines against Human Carcinomas : Strategies to Improve Antitumor Immune Responses
Joint Authors
Palena, Claudia
Schlom, Jeffrey
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Multiple observations in preclinical and clinical studies support a role for the immune system in controlling tumor growth and progression.
Various components of the innate and adaptive immune response are able to mediate tumor cell destruction; however, certain immune cell populations can also induce a protumor environment that favors tumor growth and the development of metastasis.
Moreover, tumor cells themselves are equipped with various mechanisms that allow them to evade surveillance by the immune system.
The goal of cancer vaccines is to induce a tumor-specific immune response that ultimately will reduce tumor burden by tipping the balance from a protumor to an antitumor immune environment.
This review discusses common mechanisms that govern immune cell activation and tumor immune escape, and some of the current strategies employed in the field of cancer vaccines aimed at enhancing activation of tumor-specific T-cells with concurrent reduction of immunosuppression.
American Psychological Association (APA)
Palena, Claudia& Schlom, Jeffrey. 2010. Vaccines against Human Carcinomas : Strategies to Improve Antitumor Immune Responses. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-467510
Modern Language Association (MLA)
Palena, Claudia& Schlom, Jeffrey. Vaccines against Human Carcinomas : Strategies to Improve Antitumor Immune Responses. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-467510
American Medical Association (AMA)
Palena, Claudia& Schlom, Jeffrey. Vaccines against Human Carcinomas : Strategies to Improve Antitumor Immune Responses. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-467510
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467510