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Small-Molecule Inhibitors of GSK-3 : Structural Insights and Their Application to Alzheimer's Disease Models
Joint Authors
Kramer, Thomas
Schmidt, Boris
Lo Monte, Fabio
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-32, 32 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-22
Country of Publication
Egypt
No. of Pages
32
Main Subjects
Abstract EN
The world health organization (WHO) estimated that 18 million people are struck by Alzheimer's disease (AD).
The USA, France, Germany, and other countries launched major programmes targeting the identification of risk factors, the improvement of caretaking, and fundamental research aiming to postpone the onset of AD.
The glycogen synthase kinase 3 (GSK-3) is implicated in multiple cellular processes and has been linked to the pathogenesis of several diseases including diabetes mellitus, cancer, and AD.
Inhibition of GSK-3 leads to neuroprotective effects, decreased β-amyloid production, and a reduction in tau hyperphosphorylation, which are all associated with AD.
Various classes of small molecule GSK-3 inhibitors have been published in patents and original publications.
Herein, we present a comprehensive summary of small molecules reported to interact with GSK-3.
We illustrate the interactions of the inhibitors with the active site.
Furthermore, we refer to the biological characterisation in terms of activity and selectivity for GSK-3, elucidate in vivo studies and pre-/clinical trials.
American Psychological Association (APA)
Kramer, Thomas& Schmidt, Boris& Lo Monte, Fabio. 2012. Small-Molecule Inhibitors of GSK-3 : Structural Insights and Their Application to Alzheimer's Disease Models. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-32.
https://search.emarefa.net/detail/BIM-467550
Modern Language Association (MLA)
Kramer, Thomas…[et al.]. Small-Molecule Inhibitors of GSK-3 : Structural Insights and Their Application to Alzheimer's Disease Models. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-32.
https://search.emarefa.net/detail/BIM-467550
American Medical Association (AMA)
Kramer, Thomas& Schmidt, Boris& Lo Monte, Fabio. Small-Molecule Inhibitors of GSK-3 : Structural Insights and Their Application to Alzheimer's Disease Models. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-32.
https://search.emarefa.net/detail/BIM-467550
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467550