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Reactive Oxygen Species Modulation of NaK-ATPase Regulates Fibrosis and Renal Proximal Tubular Sodium Handling
Joint Authors
Kennedy, David J.
Yan, Yanling
Liu, Jiang
Shapiro, Joseph I.
Source
International Journal of Nephrology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-23
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The Na/K-ATPase is the primary force regulating renal sodium handling and plays a key role in both ion homeostasis and blood pressure regulation.
Recently, cardiotonic steroids (CTS)-mediated Na/K-ATPase signaling has been shown to regulate fibrosis, renal proximal tubule (RPT) sodium reabsorption, and experimental Dahl salt-sensitive hypertension in response to a high-salt diet.
Reactive oxygen species (ROS) are an important modulator of nephron ion transport.
As there is limited knowledge regarding the role of ROS-mediated fibrosis and RPT sodium reabsorption through the Na/K-ATPase, the focus of this review is to examine the possible role of ROS in the regulation of Na/K-ATPase activity, its signaling, fibrosis, and RPT sodium reabsorption.
American Psychological Association (APA)
Liu, Jiang& Kennedy, David J.& Yan, Yanling& Shapiro, Joseph I.. 2012. Reactive Oxygen Species Modulation of NaK-ATPase Regulates Fibrosis and Renal Proximal Tubular Sodium Handling. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-467563
Modern Language Association (MLA)
Liu, Jiang…[et al.]. Reactive Oxygen Species Modulation of NaK-ATPase Regulates Fibrosis and Renal Proximal Tubular Sodium Handling. International Journal of Nephrology No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-467563
American Medical Association (AMA)
Liu, Jiang& Kennedy, David J.& Yan, Yanling& Shapiro, Joseph I.. Reactive Oxygen Species Modulation of NaK-ATPase Regulates Fibrosis and Renal Proximal Tubular Sodium Handling. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-467563
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467563