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The Role of Neurokinin-1 Receptor in the Microenvironment of Inflammation and Cancer
Joint Authors
Berger, Michael
Rosso, Marisa
Muñoz, Miguel
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-01
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
The recent years have witnessed an exponential increase in cancer research, leading to a considerable investment in the field.
However, with few exceptions, this effort has not yet translated into a better overall prognosis for patients with cancer, and the search for new drug targets continues.
After binding to the specific neurokinin-1 (NK-1) receptor, the peptide substance P (SP), which is widely distributed in both the central and peripheral nervous systems, triggers a wide variety of functions.
Antagonists against the NK-1 receptor are safe clinical drugs that are known to have anti-inflammatory, analgesic, anxiolytic, antidepressant, and antiemetic effects.
Recently, it has become apparent that SP can induce tumor cell proliferation, angiogenesis, and migration via the NK-1 receptor, and that the SP/NK-1 receptor complex is an integral part of the microenvironment of inflammation and cancer.
Therefore, the use of NK-1 receptor antagonists as a novel and promising approach for treating patients with cancer is currently under intense investigation.
In this paper, we evaluate the recent scientific developments regarding this receptor system, its role in the microenvironment of inflammation and cancer, and its potentials and pitfalls for the usage as part of modern anticancer strategies.Erratum to “The Role of Neurokinin-1 Receptor in the Microenvironment of Inflammation and Cancer”dx.doi.org/10.1100/2012/747912
American Psychological Association (APA)
Rosso, Marisa& Muñoz, Miguel& Berger, Michael. 2012. The Role of Neurokinin-1 Receptor in the Microenvironment of Inflammation and Cancer. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-21.
https://search.emarefa.net/detail/BIM-467574
Modern Language Association (MLA)
Rosso, Marisa…[et al.]. The Role of Neurokinin-1 Receptor in the Microenvironment of Inflammation and Cancer. The Scientific World Journal No. 2012 (2012), pp.1-21.
https://search.emarefa.net/detail/BIM-467574
American Medical Association (AMA)
Rosso, Marisa& Muñoz, Miguel& Berger, Michael. The Role of Neurokinin-1 Receptor in the Microenvironment of Inflammation and Cancer. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-21.
https://search.emarefa.net/detail/BIM-467574
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467574