Efficacy of Eosin B as a New Antimalarial Drug in a Murine Model

Abstract EN

The initial success of any adopted anti-infective strategy to malaria is followed by a descent due to the emergence of resistance to it.

The search for new drugs and drug targets is a consistent demand in this disease.

Eosin B, a common laboratory dye, is reported to have good antiparasitic properties in vitro.

It was studied for its antiparasitic effect in vivo on chloroquine-sensitive Plasmodium berghei murine malaria.

Eosin B was administered in 2 different doses by either the oral or parenteral route, once or twice daily to mice infected with Plasmodium berghei.

Both the doses of eosin B 400 mg/kg and 800 mg/kg gave better results than the controls which were 40 mg/kg chloroquine and 100 mg/kg of arteether with P<0.005 significance.

Percentage suppressive activity by Peter’s test of eosin B was better, though at a higher dose than both the controls.

Survival rate of mice receiving the higher dose of eosin B was longer than that of the controls.

When administered twice daily, the mice were fully cured after 4 days.

Eosin B seems to be a promising drug exhibiting good antimalarial effects in the murine model of the disease.