Some Pharmacodynamic Aspects of Cefepime

Joint Authors

Elsayed, Mossad Gamaleddin Ahmed
Elkomy, Ashraf Abdelhakim Ahmed
Elbadawy, Mohamed

Source

Journal of Pharmaceutics

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-11-07

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Pharmacy, Health & Medical Sciences
Economics & Business Administration
Pharmacology

Abstract EN

Some pharmacodynamic effects of cefepime, a new injectable semisynthetic cephalosporin, were studied in laboratory animals and the following results were obtained.

Cefepime maximally stimulated isolated guinea pig's ileum, rat's colon (80 μg/mL bath), and rabbit's duodenum (400 μg/mL bath).

Contrarily, complete relaxation of isolated rat's fundic strip was produced by 80 μg/mL bath.

Effects of cefepime on isolated rat's uterine muscle were different according to stage of sex cycle.

Cefepime did not induce any effects on the resting tonus of isolated guinea pig's tracheal chain and rabbit's aortic strip.

Concentrations of 200 and 400 μg/mL bath induced marked inhibition in the force of muscular twitches of the isolated frog's gastrocnemius muscle which was less potent than that induced by procaine hydrochloride 2%.

Cefepime completely blocked the neuromuscular transmission of frog's rectus abdominis muscle (40 μg/mL bath) and rat's phrenic nerve hemidiaphragm preparation (200 μg/mL bath).

This blockade was reversed by acetylcholine and neostigmine.

Cefepime produced dose-dependent negative inotropic effect on isolated rabbit's heart and guinea pig's auricles.

There were no changes in blood pressure and rate of respiration in anaesthetized dog after cefepime injection.

These findings indicate that cefepime has a low potential to produce adverse reactions at therapeutic doses.

American Psychological Association (APA)

Elsayed, Mossad Gamaleddin Ahmed& Elkomy, Ashraf Abdelhakim Ahmed& Elbadawy, Mohamed. 2012. Some Pharmacodynamic Aspects of Cefepime. Journal of Pharmaceutics،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-467625

Modern Language Association (MLA)

Elsayed, Mossad Gamaleddin Ahmed…[et al.]. Some Pharmacodynamic Aspects of Cefepime. Journal of Pharmaceutics No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-467625

American Medical Association (AMA)

Elsayed, Mossad Gamaleddin Ahmed& Elkomy, Ashraf Abdelhakim Ahmed& Elbadawy, Mohamed. Some Pharmacodynamic Aspects of Cefepime. Journal of Pharmaceutics. 2012. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-467625

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-467625