Immunosuppression Adversely Affects TST but Not IGRAs in Patients with Psoriasis or Inflammatory Musculoskeletal Diseases
Joint Authors
Kantele, Anu
Pusa, Liana
Lerisalo-Repo, Marjatta
Tavast, Esko
Eriksson, Mari
Mälkönen, Tarja
Seppälä, Ilkka
Tuuminen, Tamara
Repo, Heikki
Pakkanen, Sari H.
Järvinen, Asko
Source
International Journal of Rheumatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The performance of the interferon gamma release assays (IGRAs) and tuberculin skin test (TST) was reviewed retrospectively in patients with psoriasis, inflammatory musculoskeletal diseases, or miscellaneous inflammatory conditions.
The study was carried out over a 22-month period using 109 records of patients with psoriasis (n=21), musculoskeletal disease (n=74), or other inflammatory conditions (n=14).
Forty-four (48%) of 109 patients were on immunosuppressive therapy and 38/109 (35%) on systemic glucocorticoid therapy.
The agreement between the IGRAs was substantial (κ=0.71) whilst that between the IGRAs and TST was low (κ=0.32).
Logistic regression models revealed that IGRAs associated with risk factors for latent tuberculosis infection better than TST.
TST was influenced by age, BCG vaccination, sex, and glucocorticoid therapy.
We found that IGRAs performed equally well with low level of indeterminate results (1-2%).
IGRAs were superior to TST because the latter was influenced by BCG-vaccination status and immunosuppressive therapy.
American Psychological Association (APA)
Tavast, Esko& Tuuminen, Tamara& Pakkanen, Sari H.& Eriksson, Mari& Kantele, Anu& Järvinen, Asko…[et al.]. 2012. Immunosuppression Adversely Affects TST but Not IGRAs in Patients with Psoriasis or Inflammatory Musculoskeletal Diseases. International Journal of Rheumatology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-467629
Modern Language Association (MLA)
Tavast, Esko…[et al.]. Immunosuppression Adversely Affects TST but Not IGRAs in Patients with Psoriasis or Inflammatory Musculoskeletal Diseases. International Journal of Rheumatology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-467629
American Medical Association (AMA)
Tavast, Esko& Tuuminen, Tamara& Pakkanen, Sari H.& Eriksson, Mari& Kantele, Anu& Järvinen, Asko…[et al.]. Immunosuppression Adversely Affects TST but Not IGRAs in Patients with Psoriasis or Inflammatory Musculoskeletal Diseases. International Journal of Rheumatology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-467629
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467629