Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease : Investigation of a Possible Mechanism of Action
Joint Authors
Soumyanath, Amala
Henson, Edward
Quinn, Joseph F.
Bishop, James
Zhong, Yong-Ping
Wadsworth, Teri
Gold, Bruce G.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Centella asiatica (CA), commonly named gotu kola, is an Ayurvedic herb used to enhance memory and nerve function.
To investigate the potential use of CA in Alzheimer's disease (AD), we examined the effects of a water extract of CA (GKW) in the Tg2576 mouse, a murine model of AD with high β-amyloid burden.
Orally administered GKW attenuated β-amyloid-associated behavioral abnormalities in these mice.
In vitro, GKW protected SH-SY5Y cells and MC65 human neuroblastoma cells from toxicity induced by exogenously added and endogenously generated β-amyloid, respectively.
GKW prevented intracellular β-amyloid aggregate formation in MC65 cells.
GKW did not show anticholinesterase activity or protect neurons from oxidative damage and glutamate toxicity, mechanisms of current AD therapies.
GKW is rich in phenolic compounds and does not contain asiatic acid, a known CA neuroprotective triterpene.
CA thus offers a unique therapeutic mechanism and novel active compounds of potential relevance to the treatment of AD.
American Psychological Association (APA)
Soumyanath, Amala& Zhong, Yong-Ping& Henson, Edward& Wadsworth, Teri& Bishop, James& Gold, Bruce G.…[et al.]. 2012. Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease : Investigation of a Possible Mechanism of Action. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-467634
Modern Language Association (MLA)
Soumyanath, Amala…[et al.]. Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease : Investigation of a Possible Mechanism of Action. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-467634
American Medical Association (AMA)
Soumyanath, Amala& Zhong, Yong-Ping& Henson, Edward& Wadsworth, Teri& Bishop, James& Gold, Bruce G.…[et al.]. Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease : Investigation of a Possible Mechanism of Action. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-467634
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467634