Impaired Urine Dilution Capability in HIV Stable Patients
Joint Authors
Musso, Carlos G.
Sanchez, Marisa L.
Perelsztein, Ariel G.
de Paz Sierra, Mariana
Belloso, Waldo H.
Navarro, Matilde
Source
International Journal of Nephrology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Renal disease is a well-recognized complication among patients with HIV infection.
Viral infection itself and the use of some antiretroviral drugs contribute to this condition.
The thick ascending limb of Henle’s loop (TALH) is the tubule segment where free water clearance is generated, determining along with glomerular filtration rate the kidney’s ability to dilute urine.
Objective.
We analyzed the function of the proximal tubule and TALH in patients with HIV infection receiving or not tenofovir-containing antiretroviral treatment in comparison with healthy seronegative controls, by applying a tubular physiological test, hyposaline infusion test (Chaimowitz’ test).
Material & Methods.
Chaimowitz’ test was performed on 20 HIV positive volunteers who had normal renal functional parameters.
The control group included 10 healthy volunteers.
Results.
After the test, both HIV groups had a significant reduction of serum sodium and osmolarity compared with the control group.
Free water clearance was lower and urine osmolarity was higher in both HIV+ groups.
Proximal tubular function was normal in both studied groups.
Conclusion.
The present study documented that proximal tubule sodium reabsorption was preserved while free water clearance and maximal urine dilution capability were reduced in stable HIV patients treated or not with tenofovir.
American Psychological Association (APA)
Belloso, Waldo H.& de Paz Sierra, Mariana& Navarro, Matilde& Sanchez, Marisa L.& Perelsztein, Ariel G.& Musso, Carlos G.. 2014. Impaired Urine Dilution Capability in HIV Stable Patients. International Journal of Nephrology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-467638
Modern Language Association (MLA)
Belloso, Waldo H.…[et al.]. Impaired Urine Dilution Capability in HIV Stable Patients. International Journal of Nephrology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-467638
American Medical Association (AMA)
Belloso, Waldo H.& de Paz Sierra, Mariana& Navarro, Matilde& Sanchez, Marisa L.& Perelsztein, Ariel G.& Musso, Carlos G.. Impaired Urine Dilution Capability in HIV Stable Patients. International Journal of Nephrology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-467638
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467638