Impaired Urine Dilution Capability in HIV Stable Patients

Joint Authors

Musso, Carlos G.
Sanchez, Marisa L.
Perelsztein, Ariel G.
de Paz Sierra, Mariana
Belloso, Waldo H.
Navarro, Matilde

Source

International Journal of Nephrology

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-03-31

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Diseases
Medicine

Abstract EN

Renal disease is a well-recognized complication among patients with HIV infection.

Viral infection itself and the use of some antiretroviral drugs contribute to this condition.

The thick ascending limb of Henle’s loop (TALH) is the tubule segment where free water clearance is generated, determining along with glomerular filtration rate the kidney’s ability to dilute urine.

Objective.

We analyzed the function of the proximal tubule and TALH in patients with HIV infection receiving or not tenofovir-containing antiretroviral treatment in comparison with healthy seronegative controls, by applying a tubular physiological test, hyposaline infusion test (Chaimowitz’ test).

Material & Methods.

Chaimowitz’ test was performed on 20 HIV positive volunteers who had normal renal functional parameters.

The control group included 10 healthy volunteers.

Results.

After the test, both HIV groups had a significant reduction of serum sodium and osmolarity compared with the control group.

Free water clearance was lower and urine osmolarity was higher in both HIV+ groups.

Proximal tubular function was normal in both studied groups.

Conclusion.

The present study documented that proximal tubule sodium reabsorption was preserved while free water clearance and maximal urine dilution capability were reduced in stable HIV patients treated or not with tenofovir.

American Psychological Association (APA)

Belloso, Waldo H.& de Paz Sierra, Mariana& Navarro, Matilde& Sanchez, Marisa L.& Perelsztein, Ariel G.& Musso, Carlos G.. 2014. Impaired Urine Dilution Capability in HIV Stable Patients. International Journal of Nephrology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-467638

Modern Language Association (MLA)

Belloso, Waldo H.…[et al.]. Impaired Urine Dilution Capability in HIV Stable Patients. International Journal of Nephrology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-467638

American Medical Association (AMA)

Belloso, Waldo H.& de Paz Sierra, Mariana& Navarro, Matilde& Sanchez, Marisa L.& Perelsztein, Ariel G.& Musso, Carlos G.. Impaired Urine Dilution Capability in HIV Stable Patients. International Journal of Nephrology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-467638

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-467638