The Emerging Role of Proteolysis in Mitochondrial Quality Control and the Etiology of Parkinson’s Disease
Joint Authors
Shi, Guang
Shanbhag, Riya
McQuibban, G. Angus
Rujiviphat, Jarungjit
Source
Advances in High Energy Physics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-13
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Mitochondria are highly dynamic organelles that are important for many diverse cellular processes, such as energy metabolism, calcium buffering, and apoptosis.
Mitochondrial biology and dysfunction have recently been linked to different types of cancers and neurodegenerative diseases, most notably Parkinson’s disease.
Thus, a better understanding of the quality control systems that maintain a healthy mitochondrial network can facilitate the development of effective treatments for these diseases.
In this perspective, we will discuss recent advances on two mitochondrial quality control pathways: the UPS and mitophagy, highlight how new players may be contributing to regulate these pathways.
We believe the proteases involved will be key and novel regulators of mitochondrial quality control, and this knowledge will provide insights into future studies aimed to combat neurodegenerative diseases.
American Psychological Association (APA)
Shanbhag, Riya& Shi, Guang& Rujiviphat, Jarungjit& McQuibban, G. Angus. 2012. The Emerging Role of Proteolysis in Mitochondrial Quality Control and the Etiology of Parkinson’s Disease. Advances in High Energy Physics،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-467657
Modern Language Association (MLA)
Shanbhag, Riya…[et al.]. The Emerging Role of Proteolysis in Mitochondrial Quality Control and the Etiology of Parkinson’s Disease. Advances in High Energy Physics No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-467657
American Medical Association (AMA)
Shanbhag, Riya& Shi, Guang& Rujiviphat, Jarungjit& McQuibban, G. Angus. The Emerging Role of Proteolysis in Mitochondrial Quality Control and the Etiology of Parkinson’s Disease. Advances in High Energy Physics. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-467657
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467657