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Dynamic Changes in Sarcoplasmic Reticulum Structure in Ventricular Myocytes
Joint Authors
Santana, Luis F.
Yuan, Can
Votaw, V. Scott
Vega, Amanda L.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-01
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The fidelity of excitation-contraction (EC) coupling in ventricular myocytes is remarkable, with each action potential evoking a [Ca2+]i transient.
The prevalent model is that the consistency in EC coupling in ventricular myocytes is due to the formation of fixed, tight junctions between the sarcoplasmic reticulum (SR) and the sarcolemma where Ca2+ release is activated.
Here, we tested the hypothesis that the SR is a structurally inert organelle in ventricular myocytes.
Our data suggest that rather than being static, the SR undergoes frequent dynamic structural changes.
SR boutons expressing functional ryanodine receptors moved throughout the cell, approaching or moving away from the sarcolemma of ventricular myocytes.
These changes in SR structure occurred in the absence of changes in [Ca2+]i during EC coupling.
Microtubules and the molecular motors dynein and kinesin 1(Kif5b) were important regulators of SR motility.
These findings support a model in which the SR is a motile organelle capable of molecular motor protein-driven structural changes.
American Psychological Association (APA)
Vega, Amanda L.& Yuan, Can& Votaw, V. Scott& Santana, Luis F.. 2011. Dynamic Changes in Sarcoplasmic Reticulum Structure in Ventricular Myocytes. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-467686
Modern Language Association (MLA)
Vega, Amanda L.…[et al.]. Dynamic Changes in Sarcoplasmic Reticulum Structure in Ventricular Myocytes. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-467686
American Medical Association (AMA)
Vega, Amanda L.& Yuan, Can& Votaw, V. Scott& Santana, Luis F.. Dynamic Changes in Sarcoplasmic Reticulum Structure in Ventricular Myocytes. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-467686
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467686