Animal Models of MS Reveal Multiple Roles of Microglia in Disease Pathogenesis
Joint Authors
Source
Neurology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Multiple sclerosis (MS) is a progressive inflammatory and demyelinating disease that affects more than 2.5 million people worldwide every year.
Current therapies use mostly disease-modifying drugs, focusing on blocking and regulating systemic functions and the central nervous system (CNS) infiltration of immune cells; however, these therapies only attenuate or delay MS symptoms, but are not effective in halting the disease progression.
More recent evidence indicated that regulation of inflammation within the CNS might be a better way to approach the treatment of the disease and microglia, the resident immune cells, may be a promising target of therapeutic studies.
Microglia activation classically accompanies MS development, and regulation of microglia function changes the outcome of the disease.
In this paper, we review the contributions of microglia to MS pathogenesis and discuss microglial functions in antigen presentation, cytokine release, and phagocytosis.
We describe data both from animal and human studies.
The significant impact of the timing, intensity, and differentiation fate of activated microglia is discussed, as they can modulate MS outcomes and potentially be critically modified for future therapeutic studies.
American Psychological Association (APA)
Gao, Zhen& Tsirka, Stella E.. 2011. Animal Models of MS Reveal Multiple Roles of Microglia in Disease Pathogenesis. Neurology Research International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-467742
Modern Language Association (MLA)
Gao, Zhen& Tsirka, Stella E.. Animal Models of MS Reveal Multiple Roles of Microglia in Disease Pathogenesis. Neurology Research International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-467742
American Medical Association (AMA)
Gao, Zhen& Tsirka, Stella E.. Animal Models of MS Reveal Multiple Roles of Microglia in Disease Pathogenesis. Neurology Research International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-467742
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467742