CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease
Joint Authors
Häßler, F.
Darie, C. C.
Thome, J.
Woods, A. G.
Coogan, A. N.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-18
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Disturbed circadian rhythms with sleep problems and disrupted diurnal activity are often seen in patients suffering from Alzheimer disease (AD).
Both endogenous CLOCK genes and external Zeitgeber are responsible for the maintenance of circadian rhythmicity in humans.
Therefore, modifications of the internal CLOCK system and its interactions with exogenous factors might constitute the neurobiological basis for clinically observed disruptions in rhythmicity, which often have grave consequences for the quality of life of patients and their caregivers.
Presently, more and more data are emerging demonstrating how alterations of the CLOCK gene system might contribute to the pathophysiology of AD and other forms of dementia.
At the same time, the impact of neuropsychiatric medication on CLOCK gene expression is under investigation.
American Psychological Association (APA)
Thome, J.& Coogan, A. N.& Woods, A. G.& Darie, C. C.& Häßler, F.. 2011. CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease. Journal of Aging Research،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-467744
Modern Language Association (MLA)
Thome, J.…[et al.]. CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease. Journal of Aging Research No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-467744
American Medical Association (AMA)
Thome, J.& Coogan, A. N.& Woods, A. G.& Darie, C. C.& Häßler, F.. CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease. Journal of Aging Research. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-467744
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467744