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Severe Relapsing Goodpasture's Disease Successfully Treated with Mycophenolate Mofetil
Joint Authors
Vieira, Ana de Lurdes Agostinho Cabrita
Bernardo, Idalécio
Guedes, Anabela Malho
Neves, Pedro Leão
Pinto, Isabel
Santos, Viriato
Silva, Ana Paula
Source
International Journal of Nephrology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-16
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Goodpasture's disease is a rare autoimmune disorder characterised by the development of antiglomerular basement membrane autoantibodies, which typically presents with rapidly progressive crescentic glomerulonephritis and pulmonary haemorrhage.
Even with aggressive nonspecific immunosuppression and plasma exchange, mortality remains high.
We report a case of life-threatening Goodpasture's disease with relapsing pulmonary haemorrhage refractory to conventional therapy.
Second line treatment was based on mycophenolate mofetil 1 g every 12 hours and prednisolone 60 mg/day.
In this case, the use of a low-dose mycophenolate mofetil regimen turned out to be insufficient.
However, in our opinion higher mycophenolate mofetil doses should be considered an alternative treatment, mainly in relapsing disease, due to its mechanism of action and current insufficient therapeutic weapons.
American Psychological Association (APA)
Guedes, Anabela Malho& Santos, Viriato& Vieira, Ana de Lurdes Agostinho Cabrita& Silva, Ana Paula& Pinto, Isabel& Bernardo, Idalécio…[et al.]. 2010. Severe Relapsing Goodpasture's Disease Successfully Treated with Mycophenolate Mofetil. International Journal of Nephrology،Vol. 2010, no. 2010, pp.1-3.
https://search.emarefa.net/detail/BIM-467774
Modern Language Association (MLA)
Guedes, Anabela Malho…[et al.]. Severe Relapsing Goodpasture's Disease Successfully Treated with Mycophenolate Mofetil. International Journal of Nephrology No. 2010 (2010), pp.1-3.
https://search.emarefa.net/detail/BIM-467774
American Medical Association (AMA)
Guedes, Anabela Malho& Santos, Viriato& Vieira, Ana de Lurdes Agostinho Cabrita& Silva, Ana Paula& Pinto, Isabel& Bernardo, Idalécio…[et al.]. Severe Relapsing Goodpasture's Disease Successfully Treated with Mycophenolate Mofetil. International Journal of Nephrology. 2010. Vol. 2010, no. 2010, pp.1-3.
https://search.emarefa.net/detail/BIM-467774
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467774