Cardiac Differentiation of Pluripotent Stem Cells
Joint Authors
Aalto-Setälä, Katriina
Rajala, Kristiina
Pekkanen-Mattila, Mari
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-04
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
The ability of human pluripotent stem cells to differentiate towards the cardiac lineage has attracted significant interest, initially with a strong focus on regenerative medicine.
The ultimate goal to repair the heart by cardiomyocyte replacement has, however, proven challenging.
Human cardiac differentiation has been difficult to control, but methods are improving, and the process, to a certain extent, can be manipulated and directed.
The stem cell-derived cardiomyocytes described to date exhibit rather immature functional and structural characteristics compared to adult cardiomyocytes.
Thus, a future challenge will be to develop strategies to reach a higher degree of cardiomyocyte maturation in vitro, to isolate cardiomyocytes from the heterogeneous pool of differentiating cells, as well as to guide the differentiation into the desired subtype, that is, ventricular, atrial, and pacemaker cells.
In this paper, we will discuss the strategies for the generation of cardiomyocytes from pluripotent stem cells and their characteristics, as well as highlight some applications for the cells.
American Psychological Association (APA)
Rajala, Kristiina& Pekkanen-Mattila, Mari& Aalto-Setälä, Katriina. 2011. Cardiac Differentiation of Pluripotent Stem Cells. Stem Cells International،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-467784
Modern Language Association (MLA)
Rajala, Kristiina…[et al.]. Cardiac Differentiation of Pluripotent Stem Cells. Stem Cells International No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-467784
American Medical Association (AMA)
Rajala, Kristiina& Pekkanen-Mattila, Mari& Aalto-Setälä, Katriina. Cardiac Differentiation of Pluripotent Stem Cells. Stem Cells International. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-467784
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467784