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Insulin in Central Nervous System : More than Just a Peripheral Hormone
Joint Authors
de Oliveira, Catarina Resende
Duarte, Ana I.
Moreira, Paula I.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-21
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Insulin signaling in central nervous system (CNS) has emerged as a novel field of research since decreased brain insulin levels and/or signaling were associated to impaired learning, memory, and age-related neurodegenerative diseases.
Thus, besides its well-known role in longevity, insulin may constitute a promising therapy against diabetes- and age-related neurodegenerative disorders.
More interestingly, insulin has been also faced as the potential missing link between diabetes and aging in CNS, with Alzheimer's disease (AD) considered as the “brain-type diabetes.” In fact, brain insulin has been shown to regulate both peripheral and central glucose metabolism, neurotransmission, learning, and memory and to be neuroprotective.
And a future challenge will be to unravel the complex interactions between aging and diabetes, which, we believe, will allow the development of efficient preventive and therapeutic strategies to overcome age-related diseases and to prolong human “healthy” longevity.
Herewith, we aim to integrate the metabolic, neuromodulatory, and neuroprotective roles of insulin in two age-related pathologies: diabetes and AD, both in terms of intracellular signaling and potential therapeutic approach.
American Psychological Association (APA)
Duarte, Ana I.& Moreira, Paula I.& de Oliveira, Catarina Resende. 2012. Insulin in Central Nervous System : More than Just a Peripheral Hormone. Journal of Aging Research،Vol. 2012, no. 2012, pp.1-21.
https://search.emarefa.net/detail/BIM-467803
Modern Language Association (MLA)
Duarte, Ana I.…[et al.]. Insulin in Central Nervous System : More than Just a Peripheral Hormone. Journal of Aging Research No. 2012 (2012), pp.1-21.
https://search.emarefa.net/detail/BIM-467803
American Medical Association (AMA)
Duarte, Ana I.& Moreira, Paula I.& de Oliveira, Catarina Resende. Insulin in Central Nervous System : More than Just a Peripheral Hormone. Journal of Aging Research. 2012. Vol. 2012, no. 2012, pp.1-21.
https://search.emarefa.net/detail/BIM-467803
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467803