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Preventive Effect of TU-100 on a Type-2 Model of Colitis in Mice : Possible Involvement of Enhancing Adrenomedullin in Intestinal Epithelial Cells
Joint Authors
Kaneko, Atsushi
Tsuchiya, Naoko
Miura, Naoko
Kono, Toru
Yamamoto, Masahiro
Source
Gastroenterology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
Crohn's disease (CD) and ulcerative colitis (UC), the two major forms of inflammatory bowel disease (IBD), have histopathologically and immunologically different characteristics.
We previously reported that a traditional Japanese medicine, daikenchuto (TU-100), ameliorated a trinitrobenzenesulfonic acid- (TNBS-) induced type-1 model colitis exhibiting histopathological features of CD through adrenomedullin (ADM) enhancement.
Our current aims were to examine whether TU-100 ameliorates a type-2 model colitis that histologically resembles UC and identify the active ingredients.
Methods.
TU-100 was administered orally to mice with oxazolone- (OXN-) induced type-2 model colitis.
The morbidity was evaluated by body weight loss and the macroscopic score of colonic lesions.
ADM was quantified using an EIA kit.
Results.
TU-100 prevented weight loss and colon ulceration.
ADM production by intestinal epithelial cells was increased by TU-100 addition.
Screening to identify active ingredients showed that [6]-shogaol and hydroxy α-sanshool enhanced ADM production.
Conclusions.
TU-100 exerted a protective effect in OXN-induced type-2 model colitis, indicating that TU-100 may be a beneficial agent for treatment of UC.
American Psychological Association (APA)
Kaneko, Atsushi& Kono, Toru& Miura, Naoko& Tsuchiya, Naoko& Yamamoto, Masahiro. 2013. Preventive Effect of TU-100 on a Type-2 Model of Colitis in Mice : Possible Involvement of Enhancing Adrenomedullin in Intestinal Epithelial Cells. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-467807
Modern Language Association (MLA)
Kaneko, Atsushi…[et al.]. Preventive Effect of TU-100 on a Type-2 Model of Colitis in Mice : Possible Involvement of Enhancing Adrenomedullin in Intestinal Epithelial Cells. Gastroenterology Research and Practice No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-467807
American Medical Association (AMA)
Kaneko, Atsushi& Kono, Toru& Miura, Naoko& Tsuchiya, Naoko& Yamamoto, Masahiro. Preventive Effect of TU-100 on a Type-2 Model of Colitis in Mice : Possible Involvement of Enhancing Adrenomedullin in Intestinal Epithelial Cells. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-467807
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467807