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Antileishmanial, Toxicity, and Phytochemical Evaluation of Medicinal Plants Collected from Pakistan
Joint Authors
Shah, Naseer Ali
Khan, Muhammad Rashid
Nadhman, Akhtar
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Leishmaniasis is an important parasitic problem and is in focus for development of new drugs all over the world.
Objective of the present study was to evaluate phytochemical, toxicity, and antileishmanial potential of Jurinea dolomiaea, Asparagus gracilis, Sida cordata, and Stellaria media collected from different areas of Pakistan.
Dry powder of plants was extracted with crude methanol and fractionated with n-hexane, chloroform, ethyl acetate, n-butanol, and water solvents in escalating polarity order.
Qualitative phytochemical analysis of different class of compounds, that is, alkaloids, saponins, terpenoids, anthraquinones, cardiac glycosides, coumarins, phlobatannins, flavonoids, phenolics, and tannins, was tested.
Its appearance was observed varying with polarity of solvent used for fractionation.
Antileishmanial activity was performed against Leishmania tropica KWH23 promastigote.
Potent antileishmanial activity was observed for J.
dolomiaea methanol extract (IC50=10.9±1.1 μg/mL) in comparison to other plant extracts.
However, J.
dolomiaea “ethyl acetate fraction” was more active (IC50=5.3±0.2 μg/mL) against Leishmania tropica KWH23 among all plant fractions as well as standard Glucantime drug (6.0±0.1 μg/mL).
All the plants extract and its derived fraction exhibited toxicity in safety range (LC50 >100) in brine shrimp toxicity evaluation assay.
American Psychological Association (APA)
Shah, Naseer Ali& Khan, Muhammad Rashid& Nadhman, Akhtar. 2014. Antileishmanial, Toxicity, and Phytochemical Evaluation of Medicinal Plants Collected from Pakistan. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-467827
Modern Language Association (MLA)
Shah, Naseer Ali…[et al.]. Antileishmanial, Toxicity, and Phytochemical Evaluation of Medicinal Plants Collected from Pakistan. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-467827
American Medical Association (AMA)
Shah, Naseer Ali& Khan, Muhammad Rashid& Nadhman, Akhtar. Antileishmanial, Toxicity, and Phytochemical Evaluation of Medicinal Plants Collected from Pakistan. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-467827
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467827