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GABAergic Neuronal Precursor Grafting : Implications in Brain Regeneration and Plasticity
Joint Authors
Alvarez Dolado, Manuel
Broccoli, Vania
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Numerous neurological disorders are caused by a dysfunction of the GABAergic system that impairs or either stimulates its inhibitory action over its neuronal targets.
Pharmacological drugs have generally been proved very effective in restoring its normal function, but their lack of any sort of spatial or cell type specificity has created some limitations in their use.
In the last decades, cell-based therapies using GABAergic neuronal grafts have emerged as a promising treatment, since they may restore the lost equilibrium by cellular replacement of the missing/altered inhibitory neurons or modulating the hyperactive excitatory system.
In particular, the discovery that embryonic ganglionic eminence-derived GABAergic precursors are able to disperse and integrate in large areas of the host tissue after grafting has provided a strong rationale for exploiting their use for the treatment of diseased brains.
GABAergic neuronal transplantation not only is efficacious to restore normal GABAergic activities but can also trigger or sustain high neuronal plasticity by promoting the general reorganization of local neuronal circuits adding new synaptic connections.
These results cast new light on dynamics and plasticity of adult neuronal assemblies and their associated functions disclosing new therapeutic opportunities for the near future.
American Psychological Association (APA)
Alvarez Dolado, Manuel& Broccoli, Vania. 2011. GABAergic Neuronal Precursor Grafting : Implications in Brain Regeneration and Plasticity. Neural Plasticity،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-467830
Modern Language Association (MLA)
Alvarez Dolado, Manuel& Broccoli, Vania. GABAergic Neuronal Precursor Grafting : Implications in Brain Regeneration and Plasticity. Neural Plasticity No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-467830
American Medical Association (AMA)
Alvarez Dolado, Manuel& Broccoli, Vania. GABAergic Neuronal Precursor Grafting : Implications in Brain Regeneration and Plasticity. Neural Plasticity. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-467830
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467830