Altered Regulation of Contraction-Induced AktmTORp70S6k Pathway Signaling in Skeletal Muscle of the Obese Zucker Rat
Joint Authors
Katta, Anjaiah
Rice, Kevin M.
Karkala, S. K.
Gadde, Murali K.
Wu, Miaozong
Kolli, Madhukar
Arvapalli, Ravikumar
Paturi, Satyanarayana
Blough, Eric R.
Source
Experimental Diabetes Research
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Increased muscle loading results in the phosphorylation of the 70 kDa ribosomal S6 kinase (p70S6k), and this event is strongly correlated with the degree of muscle adaptation following resistance exercise.
Whether insulin resistance or the comorbidities associated with this disorder may affect the ability of skeletal muscle to activate p70S6k signaling following an exercise stimulus remains unclear.
Here, we compare the contraction-induced activation of p70S6k signaling in the plantaris muscles of lean and insulin resistant obese Zucker rats following a single bout of increased contractile loading.
Compared to lean animals, the basal phosphorylation of p70S6k (Thr389; 37.2% and Thr421/Ser424; 101.4%), Akt (Thr308; 25.1%), and mTOR (Ser2448; 63.0%) was higher in obese animals.
Contraction increased the phosphorylation of p70S6k (Thr389), Akt (Ser473), and mTOR (Ser2448) in both models however the magnitude and kinetics of activation differed between models.
These results suggest that contraction-induced activation of p70S6k signaling is altered in the muscle of the insulin resistant obese Zucker rat.
American Psychological Association (APA)
Katta, Anjaiah& Karkala, S. K.& Wu, Miaozong& Paturi, Satyanarayana& Gadde, Murali K.& Arvapalli, Ravikumar…[et al.]. 2010. Altered Regulation of Contraction-Induced AktmTORp70S6k Pathway Signaling in Skeletal Muscle of the Obese Zucker Rat. Experimental Diabetes Research،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-467863
Modern Language Association (MLA)
Katta, Anjaiah…[et al.]. Altered Regulation of Contraction-Induced AktmTORp70S6k Pathway Signaling in Skeletal Muscle of the Obese Zucker Rat. Experimental Diabetes Research No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-467863
American Medical Association (AMA)
Katta, Anjaiah& Karkala, S. K.& Wu, Miaozong& Paturi, Satyanarayana& Gadde, Murali K.& Arvapalli, Ravikumar…[et al.]. Altered Regulation of Contraction-Induced AktmTORp70S6k Pathway Signaling in Skeletal Muscle of the Obese Zucker Rat. Experimental Diabetes Research. 2010. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-467863
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467863