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Preparation and In VitroIn Vivo Evaluation of Vinpocetine Elementary Osmotic Pump System
Joint Authors
Mei, Xingguo
Zhou, Yue
Chen, Guojun
Ning, Mei-Ying
Source
Advances in Pharmacological Sciences
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Preparation and in vitro and in vivo evaluation of vinpocetine (VIN) elementary osmotic pump (EOP) formulations were investigated.
A method for the preparation of VIN elementary osmotic pump tablet was obtained by adding organic acid additives to increase VIN solubility.
VIN was used as the active pharmaceutical ingredient, lactose and mannitol as osmotic agent.
Citric acid was used as increasing API solubility and without resulting in the API degradation.
It is found that the VIN release rate was increasing with the citric acid amount at a constant range.
Cellulose acetate 398-3 was employed as semipermeable membrane containing polyethylene glycol 6000 and diethyl-o-phthalate as pore-forming agent and plasticizer for controlling membrane permeability.
In addition, a clear difference between the pharmacokinetic patterns of VIN immediate release and VIN elementary osmotic pump formulations was revealed.
The area under the plasma concentration-time curve after oral administration of elementary osmotic pump formulations was equivalent to VIN immediate release formulation.
Furthermore, significant differences found for mean residence time, elimination half-life, and elimination rate constant values corroborated prolonged release of VIN from elementary osmotic pump formulations.
These results suggest that the VIN osmotic pump controlled release tablets have marked controlled release characters and the VIN osmotic pump controlled release tablets and the normal tablets were bioequivalent.
American Psychological Association (APA)
Ning, Mei-Ying& Zhou, Yue& Chen, Guojun& Mei, Xingguo. 2011. Preparation and In VitroIn Vivo Evaluation of Vinpocetine Elementary Osmotic Pump System. Advances in Pharmacological Sciences،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-467937
Modern Language Association (MLA)
Ning, Mei-Ying…[et al.]. Preparation and In VitroIn Vivo Evaluation of Vinpocetine Elementary Osmotic Pump System. Advances in Pharmacological Sciences No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-467937
American Medical Association (AMA)
Ning, Mei-Ying& Zhou, Yue& Chen, Guojun& Mei, Xingguo. Preparation and In VitroIn Vivo Evaluation of Vinpocetine Elementary Osmotic Pump System. Advances in Pharmacological Sciences. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-467937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467937