Silica Nanoparticles Sensitize Human Multiple Myeloma Cells to Snake (Walterinnesia aegyptia) Venom-Induced Apoptosis and Growth Arrest
Joint Authors
Sayed, Douaa
al-Sadoon, Mohamed K.
Badr, Gamal
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Background.
Multiple myeloma (MM), an almost incurable disease, is the second most common blood cancer.
Initial chemotherapeutic treatment could be successful; however, resistance development urges the use of higher toxic doses accompanied by hematopoietic stem cell transplantation.
The establishment of more effective treatments that can overcome or circumvent chemoresistance has become a priority.
We recently demonstrated that venom extracted from Walterinnesia aegyptia (WEV) either alone or in combination with silica nanoparticles (WEV+NPs) mediated the growth arrest and apoptosis of prostate cancer cells.
In the present study, we evaluated the impact of WEV alone and WEV+NP on proliferation and apoptosis of MM cells.
Methods.
The impacts of WEV alone and WEV+NP were monitored in MM cells from 70 diagnosed patients.
The influences of WEV and WEV+NP were assessed with flow cytometry analysis.
Results.
WEV alone and WEV+NP decreased the viability of MM cells.
Using a CFSE proliferation assay, we found that WEV+NP strongly inhibited MM cell proliferation.
Furthermore, analysis of the cell cycle using the propidium iodide (PI) staining method indicated that WEV+NP strongly altered the cell cycle of MM cells and enhanced the induction of apoptosis.
Conclusions.
Our data reveal the biological effects of WEV and WEV+NP on MM cells that enable these compounds to function as effective treatments for MM.
American Psychological Association (APA)
Sayed, Douaa& al-Sadoon, Mohamed K.& Badr, Gamal. 2012. Silica Nanoparticles Sensitize Human Multiple Myeloma Cells to Snake (Walterinnesia aegyptia) Venom-Induced Apoptosis and Growth Arrest. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-468012
Modern Language Association (MLA)
Sayed, Douaa…[et al.]. Silica Nanoparticles Sensitize Human Multiple Myeloma Cells to Snake (Walterinnesia aegyptia) Venom-Induced Apoptosis and Growth Arrest. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-468012
American Medical Association (AMA)
Sayed, Douaa& al-Sadoon, Mohamed K.& Badr, Gamal. Silica Nanoparticles Sensitize Human Multiple Myeloma Cells to Snake (Walterinnesia aegyptia) Venom-Induced Apoptosis and Growth Arrest. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-468012
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468012