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Treated Follicular Lymphoma, Recurrent Invasive Pneumococcal Disease, Nonresponsiveness to Vaccination, and a Unique Pneumococcus
Joint Authors
Edwards, Giles
Paterson, Pamela
Murphy, Clare
Thom, Louise
McGoldrick, Claire
Inverarity, Donald
Mitchell, Lindsay
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-30
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
A nonneutropenic patient with treated low-grade non-Hodgkin’s (Follicular) lymphoma and secondary hypogammaglobulinemia recovered from pneumococcal pneumonia and septicemia (serotype 7F; ST191) subsequent to influenza A H1N1 (2009).
Both infections were potentially vaccine preventable.
The patient then developed pneumococcal meningitis due to a serotype 35F pneumococcus with a unique Multilocus Sequence Type (ST7004) which was not vaccine preventable.
Patient management was influenced by host predisposition to pneumococcal infection, antibiotic intolerance, and poor response to polysaccharide pneumococcal vaccine.
Indirect immunofluorescence with anti-human immunoglobulin confirmed a poor or intermediate response to Pneumovax II.
Prophylactic erythromycin was initiated, and immunoglobulin transfusions were also commenced as a preventive strategy.
ST7004 is a single locus variant of ST1635 which has been associated with the serotype 35F capsule in England.
The spi gene in ST7004, which differentiates it from ST1635, is the same as the spi gene present in ST191 which could have arisen from the first disease episode suggesting that horizontal gene transfer may have occurred between different populations of pneumococci present within the patient in an attempt to evade vaccination selection pressure.
American Psychological Association (APA)
Murphy, Clare& Inverarity, Donald& McGoldrick, Claire& Mitchell, Lindsay& Paterson, Pamela& Thom, Louise…[et al.]. 2012. Treated Follicular Lymphoma, Recurrent Invasive Pneumococcal Disease, Nonresponsiveness to Vaccination, and a Unique Pneumococcus. Case Reports in Hematology،Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-468021
Modern Language Association (MLA)
Murphy, Clare…[et al.]. Treated Follicular Lymphoma, Recurrent Invasive Pneumococcal Disease, Nonresponsiveness to Vaccination, and a Unique Pneumococcus. Case Reports in Hematology No. 2012 (2012), pp.1-3.
https://search.emarefa.net/detail/BIM-468021
American Medical Association (AMA)
Murphy, Clare& Inverarity, Donald& McGoldrick, Claire& Mitchell, Lindsay& Paterson, Pamela& Thom, Louise…[et al.]. Treated Follicular Lymphoma, Recurrent Invasive Pneumococcal Disease, Nonresponsiveness to Vaccination, and a Unique Pneumococcus. Case Reports in Hematology. 2012. Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-468021
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468021