Development of Class IIa Bacteriocins as Therapeutic Agents
Joint Authors
Lohans, Christopher T.
Vederas, John C.
Source
International Journal of Microbiology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-30
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Abstract EN
Class IIa bacteriocins have been primarily explored as natural food preservatives, but there is much interest in exploring the application of these peptides as therapeutic antimicrobial agents.
Bacteriocins of this class possess antimicrobial activity against several important human pathogens.
Therefore, the therapeutic development of these bacteriocins will be reviewed.
Biological and chemical modifications to both stabilize and increase the potency of bacteriocins are discussed, as well as the optimization of their production and purification.
The suitability of bacteriocins as pharmaceuticals is explored through determinations of cytotoxicity, effects on the natural microbiota, and in vivo efficacy in mouse models.
Recent results suggest that class IIa bacteriocins show promise as a class of therapeutic agents.
American Psychological Association (APA)
Lohans, Christopher T.& Vederas, John C.. 2011. Development of Class IIa Bacteriocins as Therapeutic Agents. International Journal of Microbiology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-468028
Modern Language Association (MLA)
Lohans, Christopher T.& Vederas, John C.. Development of Class IIa Bacteriocins as Therapeutic Agents. International Journal of Microbiology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-468028
American Medical Association (AMA)
Lohans, Christopher T.& Vederas, John C.. Development of Class IIa Bacteriocins as Therapeutic Agents. International Journal of Microbiology. 2011. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-468028
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468028