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Pleiotropic Protective Effects of Phytochemicals in Alzheimer's Disease
Joint Authors
Davinelli, Sergio
Sapere, Nadia
Zella, Davide
Bracale, Renata
Intrieri, Mariano
Scapagnini, Giovanni
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Alzheimer’s disease (AD) is a severe chronic neurodegenerative disorder of the brain characterised by progressive impairment in memory and cognition.
In the past years an intense research has aimed at dissecting the molecular events of AD.
However, there is not an exhaustive knowledge about AD pathogenesis and a limited number of therapeutic options are available to treat this neurodegenerative disease.
Consequently, considering the heterogeneity of AD, therapeutic agents acting on multiple levels of the pathology are needed.
Recent findings suggest that phytochemicals compounds with neuroprotective features may be an important resources in the discovery of drug candidates against AD.
In this paper we will describe some polyphenols and we will discuss their potential role as neuroprotective agents.
Specifically, curcumin, catechins, and resveratrol beyond their antioxidant activity are also involved in antiamyloidogenic and anti-inflammatory mechanisms.
We will focus on specific molecular targets of these selected phytochemical compounds highlighting the correlations between their neuroprotective functions and their potential therapeutic value in AD.
American Psychological Association (APA)
Davinelli, Sergio& Sapere, Nadia& Zella, Davide& Bracale, Renata& Intrieri, Mariano& Scapagnini, Giovanni. 2012. Pleiotropic Protective Effects of Phytochemicals in Alzheimer's Disease. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-468040
Modern Language Association (MLA)
Davinelli, Sergio…[et al.]. Pleiotropic Protective Effects of Phytochemicals in Alzheimer's Disease. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-468040
American Medical Association (AMA)
Davinelli, Sergio& Sapere, Nadia& Zella, Davide& Bracale, Renata& Intrieri, Mariano& Scapagnini, Giovanni. Pleiotropic Protective Effects of Phytochemicals in Alzheimer's Disease. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-468040
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468040