Smoking, DNA Adducts and Number of Risk DNA Repair Alleles in Lung Cancer Cases, in Subjects with Benign Lung Diseases and in Controls
Joint Authors
Ceppi, Marcello
Piro, Sara
Armillis, Alessandra
Peluso, Marco E. M.
Puntoni, Riccardo
Munnia, Armelle
Matullo, Giuseppe
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Smoke constituents can induce DNA adducts that cause mutations and lead to lung cancer.
We have analyzed DNA adducts and polymorphisms in two DNA repair genes, for example, XRCC1 Arg194Trp and Arg399Gln genes and XRCC3 Thr241Met gene, in 34 lung cancer cases in respect to 30 subjects with benign lung cancer disease and 40 healthy controls.
When the study population was categorized in base to the number of risk alleles, adducts were significantly increased in individuals bearing 3-4 risk alleles (OR=4.1 95% C.I.
1.28–13.09, P=.009).
A significant association with smoking was noticed in smokers for more than 40 years carrying 3-4 risk alleles (OR=36.38, 95% C.I.
1.17–1132.84, P=.040).
A not statistically significant increment of lung cancer risk was observed in the same group (OR=4.54, 95% C.I.
0.33–62.93, P=.259).
Our results suggest that the analysis of the number of risk alleles predicts the interindividual variation in DNA adducts of smokers and lung cancer cases.
American Psychological Association (APA)
Peluso, Marco E. M.& Munnia, Armelle& Piro, Sara& Armillis, Alessandra& Ceppi, Marcello& Matullo, Giuseppe…[et al.]. 2010. Smoking, DNA Adducts and Number of Risk DNA Repair Alleles in Lung Cancer Cases, in Subjects with Benign Lung Diseases and in Controls. Journal of Nucleic Acids،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-468062
Modern Language Association (MLA)
Peluso, Marco E. M.…[et al.]. Smoking, DNA Adducts and Number of Risk DNA Repair Alleles in Lung Cancer Cases, in Subjects with Benign Lung Diseases and in Controls. Journal of Nucleic Acids No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-468062
American Medical Association (AMA)
Peluso, Marco E. M.& Munnia, Armelle& Piro, Sara& Armillis, Alessandra& Ceppi, Marcello& Matullo, Giuseppe…[et al.]. Smoking, DNA Adducts and Number of Risk DNA Repair Alleles in Lung Cancer Cases, in Subjects with Benign Lung Diseases and in Controls. Journal of Nucleic Acids. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-468062
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468062