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Structural Properties, Cytotoxicity, and Anti-Inflammatory Activity of Silver(I) Complexes with tris(p-tolyl)Phosphine and 5-Chloro-2-Mercaptobenzothiazole
Joint Authors
Hadjikakou, Sotiris K.
Kourkoumelis, Nikolaos
Verginadis, I. I.
Karkabounas, Spyros
Gouma, E.
Hursthouse, M. B.
Male, L.
Kubicki, Maciej
Kyros, L.
Charalabopoulos, K.
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The synthesis and characterization of the silver(I) chloride complex of formula {[AgCI(CMBZT)(TPTP)2]⋅(MeOH)} (1) (CMBZT = 5-chloro-2-mercaptobenzothiazole, TPTP = tris(p-tolyl)phosphine) is described.
Also the structure of the hydrate derivative {[AgCI(TPTP)3]⋅(0.5⋅H2O)} (2) of the corresponding known anhydrous silver complex (Zartilas et al., 2009), and the polymorph 3 of the known [AgI(TPTP)3] complex (Zartilas et al., 2009) were determined and compared with the known ones.
In addition, the structure of the known one silver(I) cluster {[AgI(TPTP)]4} (4) (Meijboom et al., 2009) was re-determined at 120(2) K and possible Ag-Ag interactions were analyzed.
The compounds 1–4 were characterized by X-ray crystallography at r.t (1) and 120 K (2–4).
All these complexes and {[(Et3NH)+]2⋅[Ag6(μ3-Hmna)4(μ3-mna)2]2−⋅(DMSO)2⋅(H2O)} (5) (Hmna = 2-mercaptonicotinic acid) were evaluated for cytotoxic and anti-inflammatory activity.
The in vitro testing of cytotoxic activity of 1–5 against leiomyosarcoma cancer cells (LMS), were evaluated with Trypan Blue and Thiazolyl Blue Tetrazolium Bromide or 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) assays.
The flow cytometry assay for complex 1 and showed that at 15 μM of 1, 62.38% of LMS cells undergo apoptosis, while 7% of LMS cells undergo cell necrosis.
The antitumor activity of 3 is comparable with that of its reported polymorph (Zartilas et al., 2009).
The anti-inflammatory, activity of complexes 1–3 and 5 was also studied.
The activity towards cell viability was 2>3>5>1>4, while the order of the inhibitory activity in cell growth proliferation follows the order, 2>3>1>4>5.
The anti-inflammatory activity on the other hand is 1>2>5>⋯>3.
American Psychological Association (APA)
Kyros, L.& Kourkoumelis, Nikolaos& Kubicki, Maciej& Male, L.& Hursthouse, M. B.& Verginadis, I. I.…[et al.]. 2010. Structural Properties, Cytotoxicity, and Anti-Inflammatory Activity of Silver(I) Complexes with tris(p-tolyl)Phosphine and 5-Chloro-2-Mercaptobenzothiazole. Bioinorganic Chemistry and Applications،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-468069
Modern Language Association (MLA)
Kyros, L.…[et al.]. Structural Properties, Cytotoxicity, and Anti-Inflammatory Activity of Silver(I) Complexes with tris(p-tolyl)Phosphine and 5-Chloro-2-Mercaptobenzothiazole. Bioinorganic Chemistry and Applications No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-468069
American Medical Association (AMA)
Kyros, L.& Kourkoumelis, Nikolaos& Kubicki, Maciej& Male, L.& Hursthouse, M. B.& Verginadis, I. I.…[et al.]. Structural Properties, Cytotoxicity, and Anti-Inflammatory Activity of Silver(I) Complexes with tris(p-tolyl)Phosphine and 5-Chloro-2-Mercaptobenzothiazole. Bioinorganic Chemistry and Applications. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-468069
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468069