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Report of the Pilot Study Done for the Proposed Investigation on the Possible Synergic Effect between High-Dose Ascorbic Acid Application and Oncothermia Treatment
Joint Authors
Kovago, Csaba
Andocs, Gabor
Szász, András
Meggyeshazi, Nora
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-2, 2 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-23
Country of Publication
Egypt
No. of Pages
2
Main Subjects
Abstract EN
According to recent investigations, the parenteral application of ascorbic acid (vitamin C) at high doses has significant antitumor activity in in vitro assays.
The goal of our experiment was to determine the possible potentiating effect of application of high dose pH-neutralized ascorbic acid to the normal oncothermia treatment method.
The NMRI mice were inoculated with C26 murine colon carcinoma cell line subcutaneously at both of their femoral regions and were kept till the tumors reached symmetrically 10 mm in diameter.
We created four experimental groups, containing 5 male and 5 female animals in each.
Both vitamin-C and oncothermia treatments were applied once; ascorbic acid was applied intra-peritoneally.
Oncothermia treatment was applied only to the right limb tumor; the other side will be used as internal control.
After the treatment, the animals were sacrificed, and all tumors were removed and analyzed histopathologically.
Our main question centers on the comparison of the cell destruction ratio of the various applied treatment regimes, and studies the possible synergy or additive cross-potentiating of the methods.
The results of this experiment turned out to be controversial, since the ascorbic acid did not change the remission rate of the allografts and showed no synergy with oncothermia.
American Psychological Association (APA)
Kovago, Csaba& Meggyeshazi, Nora& Andocs, Gabor& Szász, András. 2013. Report of the Pilot Study Done for the Proposed Investigation on the Possible Synergic Effect between High-Dose Ascorbic Acid Application and Oncothermia Treatment. Conference Papers in Medicine،Vol. 2013, no. 2013, pp.1-2.
https://search.emarefa.net/detail/BIM-468077
Modern Language Association (MLA)
Kovago, Csaba…[et al.]. Report of the Pilot Study Done for the Proposed Investigation on the Possible Synergic Effect between High-Dose Ascorbic Acid Application and Oncothermia Treatment. Conference Papers in Medicine No. 2013 (2013), pp.1-2.
https://search.emarefa.net/detail/BIM-468077
American Medical Association (AMA)
Kovago, Csaba& Meggyeshazi, Nora& Andocs, Gabor& Szász, András. Report of the Pilot Study Done for the Proposed Investigation on the Possible Synergic Effect between High-Dose Ascorbic Acid Application and Oncothermia Treatment. Conference Papers in Medicine. 2013. Vol. 2013, no. 2013, pp.1-2.
https://search.emarefa.net/detail/BIM-468077
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468077