DNA Damage in Inflammation-Related Carcinogenesis and Cancer Stem Cells
Joint Authors
Hammam, Olfat
Pinlaor, Somchai
Ma, Ning
Ohnishi, Shiho
Kawanishi, Shosuke
Thanan, Raynoo
Murata, Mariko
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Infection and chronic inflammation have been recognized as important factors for carcinogenesis.
Under inflammatory conditions, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from inflammatory and epithelial cells and result in oxidative and nitrative DNA damage, such as 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) and 8-nitroguanine.
The DNA damage can cause mutations and has been implicated in the initiation and/or promotion of inflammation-mediated carcinogenesis.
It has been estimated that various infectious agents are carcinogenic to humans (IARC group 1), including parasites (Schistosoma haematobium (SH) and Opisthorchis viverrini (OV)), viruses (hepatitis C virus (HCV), human papillomavirus (HPV), and Epstein-Barr virus (EBV)), and bacterium Helicobacter pylori (HP).
SH, OV, HCV, HPV, EBV, and HP are important risk factors for bladder cancer, cholangiocarcinoma, hepatocellular carcinoma, cervical cancer, nasopharyngeal carcinoma, and gastric cancer, respectively.
We demonstrated that 8-nitroguanine was strongly formed via inducible nitric oxide synthase (iNOS) expression at these cancer sites of patients.
Moreover, 8-nitroguanine was formed in Oct3/4-positive stem cells in SH-associated bladder cancer tissues and in Oct3/4- and CD133-positive stem cells in OV-associated cholangiocarcinoma tissues.
Therefore, it is considered that oxidative and nitrative DNA damage in stem cells may play a key role in inflammation-related carcinogenesis.
American Psychological Association (APA)
Ohnishi, Shiho& Ma, Ning& Thanan, Raynoo& Pinlaor, Somchai& Hammam, Olfat& Murata, Mariko…[et al.]. 2013. DNA Damage in Inflammation-Related Carcinogenesis and Cancer Stem Cells. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-468091
Modern Language Association (MLA)
Ohnishi, Shiho…[et al.]. DNA Damage in Inflammation-Related Carcinogenesis and Cancer Stem Cells. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-468091
American Medical Association (AMA)
Ohnishi, Shiho& Ma, Ning& Thanan, Raynoo& Pinlaor, Somchai& Hammam, Olfat& Murata, Mariko…[et al.]. DNA Damage in Inflammation-Related Carcinogenesis and Cancer Stem Cells. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-468091
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468091