Bone Health in a Nonjaundiced Population of Children with Biliary Atresia
Joint Authors
Arvay-Nezu, Jessica L.
Stallings, Virginia A.
Haber, Barbara A.
Kramer, Rachel A.
Zemel, Babette S.
Leonard, Mary B.
Source
Gastroenterology Research and Practice
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-07-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objectives.
To assess bone health in a cohort of nonjaundiced children with biliary atresia (BA) and the effect of growth and development on bone outcomes.
Methods.
Children ages one to eighteen years receiving care from Children's Hospital of Philadelphia were recruited.
Each child was seen once and assessed for growth, pubertal development, concurrent medications, bilirubin, ALT, albumin, vitamin D status, bone mineral density (BMD), and bone mineral content (BMC) of the lumbar spine and whole body.
Results.
BMD declined significantly with age, and upon further analysis with a well-phenotyped control cohort, it was found that BMC was significantly decreased for both lumbar spine and whole body, even after adjustment for confounding variables.
An age interaction was identified, with older subjects having a significantly greater impairment in BMC.
Conclusions.
These preliminary results demonstrate that children with BA, including those without jaundice, are likely to have compromised bone health even when accounting for height and puberty, which are common confounding factors in chronic disease.
Further investigation is needed to identify the determinants of poor bone mineral status and to develop strategies to prevent osteoporosis later in life.
American Psychological Association (APA)
Kramer, Rachel A.& Zemel, Babette S.& Arvay-Nezu, Jessica L.& Stallings, Virginia A.& Leonard, Mary B.& Haber, Barbara A.. 2009. Bone Health in a Nonjaundiced Population of Children with Biliary Atresia. Gastroenterology Research and Practice،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-468095
Modern Language Association (MLA)
Kramer, Rachel A.…[et al.]. Bone Health in a Nonjaundiced Population of Children with Biliary Atresia. Gastroenterology Research and Practice No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-468095
American Medical Association (AMA)
Kramer, Rachel A.& Zemel, Babette S.& Arvay-Nezu, Jessica L.& Stallings, Virginia A.& Leonard, Mary B.& Haber, Barbara A.. Bone Health in a Nonjaundiced Population of Children with Biliary Atresia. Gastroenterology Research and Practice. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-468095
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468095