Flow Cytometric Detection of the Classical Hodgkin Lymphoma : Clinical and Research Applications
Joint Authors
Wood, Brent L.
Roshal, Mikhail
Fromm, Jonathan R.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Classical Hodgkin lymphoma (CHL) is a relatively uncommon B cell-derived neoplasm that presents with rare malignant cells in an abundant reactive background.
The diagnosis of CHL currently relies on a combination of morphologic findings and immunohistochemical stains.
With the exception of rare cases with dramatically increased malignant populations, isolation of pure viable tumor cells has not been historically possible.
Recently, a reliable flow cytometric assay for direct detection and isolation of the malignant cells in this disease has been developed.
This assay has proven useful diagnostically and has been clinically validated to have a very high sensitivity and nearly absolute specificity for the diagnosis of CHL in routine clinical samples.
This paper describes the methodology for the flow cytometric detection of CHL in clinical samples as well as current state of evaluation of background lymphocytes as an adjunct diagnostic test.
Also discussed are exciting research applications of the direct isolation of viable tumor cells in CHL.
The current state of flow cytometric evaluation of nodular lymphocyte predominant Hodgkin lymphoma and T cell-rich large B cell lymphoma is also briefly discussed.
American Psychological Association (APA)
Roshal, Mikhail& Wood, Brent L.& Fromm, Jonathan R.. 2010. Flow Cytometric Detection of the Classical Hodgkin Lymphoma : Clinical and Research Applications. Advances in Hematology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-468096
Modern Language Association (MLA)
Roshal, Mikhail…[et al.]. Flow Cytometric Detection of the Classical Hodgkin Lymphoma : Clinical and Research Applications. Advances in Hematology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-468096
American Medical Association (AMA)
Roshal, Mikhail& Wood, Brent L.& Fromm, Jonathan R.. Flow Cytometric Detection of the Classical Hodgkin Lymphoma : Clinical and Research Applications. Advances in Hematology. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-468096
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468096