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The Effect of Electroacupuncture on Osteosarcoma Tumor Growth and Metastasis : Analysis of Different Treatment Regimens
Joint Authors
O’Brien, Elaine E.
al-Gizawiy, Mona
Ericson, Marna E.
Beitz, Alvin J.
Smeester, Branden A.
Triemstra, Jennifer L.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Osteosarcoma is the most common malignant bone tumor found in children and adolescents and is associated with many complications including cancer pain and metastasis.
While cancer patients often seek complementary and alternative medicine (CAM) approaches to treat cancer pain and fatigue or the side effects of chemotherapy and treatment, there is little known about the effect of acupuncture treatment on tumor growth and metastasis.
Here we evaluate the effects of six different electroacupuncture (EA) regimens on osteosarcoma tumor growth and metastasis in both male and female mice.
The most significant positive effects were observed when EA was applied to the ST-36 acupoint twice weekly (EA-2X/3) beginning at postimplantation day 3 (PID 3).
Twice weekly treatment produced robust reductions in tumor growth.
Conversely, when EA was applied twice weekly (EA-2X/7), starting at PID 7, there was a significant increase in tumor growth.
We further demonstrate that EA-2X/3 treatment elicits significant reductions in tumor lymphatics, vasculature, and innervation.
Lastly, EA-2X/3 treatment produced a marked reduction in pulmonary metastasis, thus providing evidence for EA’s potential antimetastatic capabilities.
Collectively, EA-2X/3 treatment was found to reduce both bone tumor growth and lung metastasis, which may be mediated in part through reductions in tumor-associated vasculature, lymphatics, and innervation.
American Psychological Association (APA)
Smeester, Branden A.& al-Gizawiy, Mona& O’Brien, Elaine E.& Ericson, Marna E.& Triemstra, Jennifer L.& Beitz, Alvin J.. 2013. The Effect of Electroacupuncture on Osteosarcoma Tumor Growth and Metastasis : Analysis of Different Treatment Regimens. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-468115
Modern Language Association (MLA)
Smeester, Branden A.…[et al.]. The Effect of Electroacupuncture on Osteosarcoma Tumor Growth and Metastasis : Analysis of Different Treatment Regimens. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-468115
American Medical Association (AMA)
Smeester, Branden A.& al-Gizawiy, Mona& O’Brien, Elaine E.& Ericson, Marna E.& Triemstra, Jennifer L.& Beitz, Alvin J.. The Effect of Electroacupuncture on Osteosarcoma Tumor Growth and Metastasis : Analysis of Different Treatment Regimens. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-468115
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468115