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Mitochondrial Roles and Cytoprotection in Chronic Liver Injury
Joint Authors
Saffroy, Raphaël
Pommier, Alban
Hamelin, Jocelyne
Degli Esposti, Davide
Lemoine, Antoinette
Bosselut, Nelly
Martel, Cécile
Sebagh, Mylène
Source
Biochemistry Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-15
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The liver is one of the richest organs in terms of number and density of mitochondria.
Most chronic liver diseases are associated with the accumulation of damaged mitochondria.
Hepatic mitochondria have unique features compared to other organs' mitochondria, since they are the hub that integrates hepatic metabolism of carbohydrates, lipids and proteins.
Mitochondria are also essential in hepatocyte survival as mediator of apoptosis and necrosis.
Hepatocytes have developed different mechanisms to keep mitochondrial integrity or to prevent the effects of mitochondrial lesions, in particular regulating organelle biogenesis and degradation.
In this paper, we will focus on the role of mitochondria in liver physiology, such as hepatic metabolism, reactive oxygen species homeostasis and cell survival.
We will also focus on chronic liver pathologies, especially those linked to alcohol, virus, drugs or metabolic syndrome and we will discuss how mitochondria could provide a promising therapeutic target in these contexts.
American Psychological Association (APA)
Degli Esposti, Davide& Hamelin, Jocelyne& Bosselut, Nelly& Saffroy, Raphaël& Sebagh, Mylène& Pommier, Alban…[et al.]. 2012. Mitochondrial Roles and Cytoprotection in Chronic Liver Injury. Biochemistry Research International،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-468163
Modern Language Association (MLA)
Degli Esposti, Davide…[et al.]. Mitochondrial Roles and Cytoprotection in Chronic Liver Injury. Biochemistry Research International No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-468163
American Medical Association (AMA)
Degli Esposti, Davide& Hamelin, Jocelyne& Bosselut, Nelly& Saffroy, Raphaël& Sebagh, Mylène& Pommier, Alban…[et al.]. Mitochondrial Roles and Cytoprotection in Chronic Liver Injury. Biochemistry Research International. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-468163
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468163