Different Modulating Effects of Adenosine on Neonatal and Adult Polymorphonuclear Leukocytes
Joint Authors
Wang, Lin
Ou, Chia-Yu
Sheen, Jiunn-Ming
Cheng, Wen-Hsin
Kuo, Ho-Chang
Lin, Li-Yan
Jheng, Yi-Jyun
Hou, Pei-Chen
Yang, Kuender D.
Yu, Hong-Ren
Hsu, Te-Yao
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Polymorphonuclear leukocytes (PMNs) are the major leukocytes in the circulation and play an important role in host defense.
Intact PMN functions include adhesion, migration, phagocytosis, and reactive oxygen species (ROS) release.
It has been known for a long time that adenosine can function as a modulator of adult PMN functions.
Neonatal plasma has a higher adenosine level than that of adults; however, little is known about the modulating effects of adenosine on neonatal PMNs.
The aim of this study was to investigate the effects of adenosine on neonatal PMN functions.
We found that neonatal PMNs had impaired adhesion, chemotaxis, and ROS production abilities, but not phagocytosis compared to adult PMNs.
As with adult PMNs, adenosine could suppress the CD11b expressions of neonatal PMNs, but had no significant suppressive effect on phagocytosis.
In contrast to adult PMNs, adenosine did not significantly suppress chemotaxis and ROS production of neonatal PMNs.
This may be due to impaired phagocyte reactions and a poor neonatal PMN response to adenosine.
Adenosine may not be a good strategy for the treatment of neonatal sepsis because of impaired phagocyte reactions and poor response.
American Psychological Association (APA)
Hou, Pei-Chen& Yu, Hong-Ren& Kuo, Ho-Chang& Wang, Lin& Lin, Li-Yan& Sheen, Jiunn-Ming…[et al.]. 2012. Different Modulating Effects of Adenosine on Neonatal and Adult Polymorphonuclear Leukocytes. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-468182
Modern Language Association (MLA)
Hou, Pei-Chen…[et al.]. Different Modulating Effects of Adenosine on Neonatal and Adult Polymorphonuclear Leukocytes. The Scientific World Journal No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-468182
American Medical Association (AMA)
Hou, Pei-Chen& Yu, Hong-Ren& Kuo, Ho-Chang& Wang, Lin& Lin, Li-Yan& Sheen, Jiunn-Ming…[et al.]. Different Modulating Effects of Adenosine on Neonatal and Adult Polymorphonuclear Leukocytes. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-468182
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468182