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A Parametric Study on the Immunomodulatory Effects of Electroacupuncture in DNP-KLH Immunized Mice
Joint Authors
Kim, Sun Kwang
Bae, Hyunsu
Hong, Moo-Chang
Koo, Sungtae
Choi, Sun-Mi
Min, Byung-Il
Lee, Young Seop
Shin, Min-Kyu
Cho, Hyunjoo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
This study was conducted to compare the effects of low frequency electroacupuncture (EA) and high frequency EA at acupoint ST36 on the production of IgE and Th1/Th2 cytokines in BALB/c mice that had been immunized with 2,4-dinitrophenylated keyhole limpet protein (DNP-KLH), as well as to investigate the difference in the immunomodulatory effects exerted by EA stimulations at acupoint ST36 and at a non-acupoint (tail).
Female BALB/c mice were divided into seven groups: normal (no treatments), IM (immunization only), ST36-PA (IM + plain acupuncture at ST36), ST36-LEA (IM + low frequency (1 Hz) EA at ST36), ST36-HEA (IM + high frequency (120 Hz) EA at ST36), NA-LEA (IM + low frequency (1 Hz) EA at non-acupoint) and NA-HEA (IM + high frequency (120 Hz) EA at non-acupoint).
EA stimulation was performed daily for two weeks, and total IgE, DNP-KLH specific IgE, IL-4 and IFN-γ levels were measured at the end of the experiment.
The results of this study showed that the IgE and IL-4 levels were significantly suppressed in the ST36-LEA and ST36-HEA groups, but not in the NA-LEA and NA-HEA groups.
However, there was little difference in the immunomodulatory effects observed in the ST36-LEA and ST36-HEA groups.
Taken together, these results suggest that EA stimulation-induced immunomodulation is not frequency dependent, but that it is acupoint specific.
American Psychological Association (APA)
Kim, Sun Kwang& Lee, Young Seop& Cho, Hyunjoo& Koo, Sungtae& Choi, Sun-Mi& Shin, Min-Kyu…[et al.]. 2011. A Parametric Study on the Immunomodulatory Effects of Electroacupuncture in DNP-KLH Immunized Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-468194
Modern Language Association (MLA)
Kim, Sun Kwang…[et al.]. A Parametric Study on the Immunomodulatory Effects of Electroacupuncture in DNP-KLH Immunized Mice. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-468194
American Medical Association (AMA)
Kim, Sun Kwang& Lee, Young Seop& Cho, Hyunjoo& Koo, Sungtae& Choi, Sun-Mi& Shin, Min-Kyu…[et al.]. A Parametric Study on the Immunomodulatory Effects of Electroacupuncture in DNP-KLH Immunized Mice. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-468194
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468194