Il-6 Serum Levels and Production Is Related to an Altered Immune Response in Polycystic Ovary Syndrome Girls with Insulin Resistance

Joint Authors

Fulghesu, Anna M.
Magnini, Roberta
Uda, Sabrina
Sanna, Francesca
Batetta, Barbara
Portoghese, Elaine

Source

Mediators of Inflammation

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-03-20

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Diseases

Abstract EN

Polycystic ovarian syndrome (PCOS) is frequently characterized by obesity and metabolic diseases including hypertension, insulin resistance, and diabetes in adulthood, all leading to an increased risk of atherosclerosis.

The present study aimed to evaluate serum and production of inflammatory markers in adolescent Sardinian PCOS.

On the basis of HOMA findings, patients were divided into noninsulin resistant (NIR) and insulin resistant (IR), and were weight- and age-matched with healthy girls.

Inflammatory cytokines (TNF-α, IL-6, Il-10, TGF-β) and lipokines (leptin, adiponectin), the reactant hs-CRP, and in vitro inflammatory lympho-monocyte response to microbial stimulus were evaluated.

In healthy and PCOS subjects, leptin and hs-CRP were correlated with BMI, whereas adiponectin was significantly reduced in all PCOS groups.

Although cytokines were similar in all groups, Interleukin-6 (IL-6) was significantly higher in IR PCOS.

Moreover, in the latter group lipopolysaccharide-activated monocytes secreted significantly higher levels of IL-6 compared to NIR and control subjects.

To conclude, IR PCOS displayed increased IL-6 serum levels and higher secretion in LPS-activated monocytes, whilst revealing no differences for other inflammatory cytokines.

These results suggest that in PCOS patients an altered immune response to inflammatory stimuli is present in IR, likely contributing towards determining onset of a low grade inflammation.

American Psychological Association (APA)

Fulghesu, Anna M.& Sanna, Francesca& Uda, Sabrina& Magnini, Roberta& Portoghese, Elaine& Batetta, Barbara. 2011. Il-6 Serum Levels and Production Is Related to an Altered Immune Response in Polycystic Ovary Syndrome Girls with Insulin Resistance. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-468220

Modern Language Association (MLA)

Fulghesu, Anna M.…[et al.]. Il-6 Serum Levels and Production Is Related to an Altered Immune Response in Polycystic Ovary Syndrome Girls with Insulin Resistance. Mediators of Inflammation No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-468220

American Medical Association (AMA)

Fulghesu, Anna M.& Sanna, Francesca& Uda, Sabrina& Magnini, Roberta& Portoghese, Elaine& Batetta, Barbara. Il-6 Serum Levels and Production Is Related to an Altered Immune Response in Polycystic Ovary Syndrome Girls with Insulin Resistance. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-468220

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-468220