Exploring the Relationship between the Inhibition Selectivity and the Apoptosis of Roscovitine-Treated Cancer Cells
Joint Authors
Wang, Yuji
Zhao, Ming
Wang, Yaonan
Peng, Shiqi
Cui, Chunying
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The antitumor activity of roscovitine was tested in four cervical carcinoma cells: C33A, HCE-1, HeLa, and SiHa.
The effects of roscovitine on ATP Lite assay, cell cycle, and apoptosis were assessed.
The Sub-G1 DNA content occurred great increasing, and this indicates that apoptosis was induced quickly in HeLa cells, but slowly in the other cells.
The morphological observation results showed that roscovitine induced apoptosis and cell death in the cervical carcinoma cells.
Results revealed that roscovitine exhibited selective cytotoxicity towards 4 cervical carcinoma cells, and the cells showed different morphologic and apoptotic changes at the same concentration.
It was estimated that cervical carcinoma cells responded differently to roscovitine because of differences in apoptotic and genetic background in different cervical carcinoma cells.
This study suggested that roscovitine had the potential to be a chemotherapeutic agent against cervical carcinoma.
American Psychological Association (APA)
Cui, Chunying& Wang, Yaonan& Wang, Yuji& Zhao, Ming& Peng, Shiqi. 2013. Exploring the Relationship between the Inhibition Selectivity and the Apoptosis of Roscovitine-Treated Cancer Cells. Journal of Analytical Methods in Chemistry،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-468228
Modern Language Association (MLA)
Cui, Chunying…[et al.]. Exploring the Relationship between the Inhibition Selectivity and the Apoptosis of Roscovitine-Treated Cancer Cells. Journal of Analytical Methods in Chemistry No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-468228
American Medical Association (AMA)
Cui, Chunying& Wang, Yaonan& Wang, Yuji& Zhao, Ming& Peng, Shiqi. Exploring the Relationship between the Inhibition Selectivity and the Apoptosis of Roscovitine-Treated Cancer Cells. Journal of Analytical Methods in Chemistry. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-468228
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468228