Peroxisome Proliferator-Activated Receptor and Age-Related Macular Degeneration
Joint Authors
Herzlich, Alexandra A.
Chan, Chi-Chao
Tuo, Jingsheng
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-01-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Age-related macular degeneration (AMD) is the leading cause of new blindness in the western world and is becoming more of a socio-medical problem as the proportion of the aged population increases.
There are multiple efforts underway to better understand this disease process.
AMD involves the abnormal retinal pigment epithelium (RPE), drusen formation, photoreceptor atrophy, and choroidal neovascularization.
Peroxisome proliferator-activated receptors (PPARs) play an important role in lipid degeneration, immune regulation, regulation of reactive oxygen species (ROSs), as well as regulation of vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), and docosahexaenoic acid (DHA).
These molecules have all been implicated in the pathogenesis of AMD.
In addition, PPAR gamma is expressed in RPE, an essential cell in photoreceptor regeneration and vision maintenance.
This review summarizes the interactions between PPAR, AMD-related molecules, and AMD-related disease processes.
American Psychological Association (APA)
Herzlich, Alexandra A.& Tuo, Jingsheng& Chan, Chi-Chao. 2008. Peroxisome Proliferator-Activated Receptor and Age-Related Macular Degeneration. PPAR Research،Vol. 2008, no. 2008, pp.1-11.
https://search.emarefa.net/detail/BIM-468240
Modern Language Association (MLA)
Herzlich, Alexandra A.…[et al.]. Peroxisome Proliferator-Activated Receptor and Age-Related Macular Degeneration. PPAR Research No. 2008 (2008), pp.1-11.
https://search.emarefa.net/detail/BIM-468240
American Medical Association (AMA)
Herzlich, Alexandra A.& Tuo, Jingsheng& Chan, Chi-Chao. Peroxisome Proliferator-Activated Receptor and Age-Related Macular Degeneration. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-11.
https://search.emarefa.net/detail/BIM-468240
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468240