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Synthesis of PET-PLADrug Nanoparticles and Their Effect with Gold Nanoparticles for Controlled Drug Release in Cancer Chemotherapy
Joint Authors
Alagar, M.
Kumar, K. Sathish
Selvaraj, V.
Source
Research Letters in Nanotechnology
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-29
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Chemistry
Information Technology and Computer Science
Science
Abstract EN
Polyethylene terephthalate-polylactic acid copolymer (PET-PLA) was synthesized from bis (2-hydroxyethyl terephthalate) and L-lactic acid oligomer in the presence of manganese antimony glycoxide as a catalyst.
The synthesized PET-PLA copolymer was used for controlled drug release systems with gold nanoparticles.
Fluorouracil containing PET-PLA nanocapsules was prepared in the presence of gold nanoparticles by solvent evaporation method.
The morphologies of the nanocapsules were characterized using scanning electron microscopy and transmission electron microscopy.
Controlled release of Fu and Fu@Au was carried out in 0.1 M phosphate buffer (pH 7.4) and 0.1 M HCl solution.
The results indicated that the drug release for gold nanoparticles/fluorouracil (Au@Fu) incorporated PET-PLA nanocapsules was controlled and slow compared to Fu incorporated PET-PLA nanocapsules.
This may be due to the interaction between the gold nanoparticles and fluorouracil in PET-PLA nanocapsules.
American Psychological Association (APA)
Kumar, K. Sathish& Selvaraj, V.& Alagar, M.. 2012. Synthesis of PET-PLADrug Nanoparticles and Their Effect with Gold Nanoparticles for Controlled Drug Release in Cancer Chemotherapy. Research Letters in Nanotechnology،Vol. 2008, no. 2008, pp.1-4.
https://search.emarefa.net/detail/BIM-468241
Modern Language Association (MLA)
Kumar, K. Sathish…[et al.]. Synthesis of PET-PLADrug Nanoparticles and Their Effect with Gold Nanoparticles for Controlled Drug Release in Cancer Chemotherapy. Research Letters in Nanotechnology No. 2008 (2008), pp.1-4.
https://search.emarefa.net/detail/BIM-468241
American Medical Association (AMA)
Kumar, K. Sathish& Selvaraj, V.& Alagar, M.. Synthesis of PET-PLADrug Nanoparticles and Their Effect with Gold Nanoparticles for Controlled Drug Release in Cancer Chemotherapy. Research Letters in Nanotechnology. 2012. Vol. 2008, no. 2008, pp.1-4.
https://search.emarefa.net/detail/BIM-468241
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468241